Marthiapeptide A, an Anti-infective and Cytotoxic Polythiazole Cyclopeptide from a 60 L Scale Fermentation of the Deep Sea-Derived Marinactinospora thermotolerans SCSIO 00652
文献类型：期刊论文
| 作者 | Chen, YC; Huang, HB; Zhou, X; Hua, Y; Tian, XP; Zou, JH; Song, YX; Tan, JH; jju@scsio.ac.cn; Ju, JH |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2012 |
| 卷号 | 75期号:12页码:2251-2255 |
| ISSN号 | 0163-3864 |
| 英文摘要 | A new sequential tristhiazole-thiazoline-containing cyclic peptide, marthiapeptide A (1), was isolated from a 60 L scale culture of the deep South China Sea-derived strain Marinactinospora thermotolerans SCSIO 00652. The planar structure and absolute configuration of 1 were elucidated by application of spectroscopic techniques, as well as by single-crystal X-ray diffraction and chiral-phase HPLC analysis of the acid hydrolysates. Marthiapeptide A (1) exhibited antibacterial activity against a panel of Gram-positive bacteria, with MIC values ranging from 2.0 to 8.0 mu g/mL, and displayed strong cytotoxic activity against a panel of human cancer cell lines with IC50 values ranging from 0.38 to 0.52 mu M. |
| 学科主题 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 资助项目 | LMB |
| 语种 | 英语 |
| WOS记录号 | WOS:000312823300031 |
| 公开日期 | 2013-08-28 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/9736]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 通讯作者 | jju@scsio.ac.cn |
| 推荐引用方式 GB/T 7714 | Chen, YC,Huang, HB,Zhou, X,et al. Marthiapeptide A, an Anti-infective and Cytotoxic Polythiazole Cyclopeptide from a 60 L Scale Fermentation of the Deep Sea-Derived Marinactinospora thermotolerans SCSIO 00652[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(12):2251-2255. |
| APA | Chen, YC.,Huang, HB.,Zhou, X.,Hua, Y.,Tian, XP.,...&Ju, JH.(2012).Marthiapeptide A, an Anti-infective and Cytotoxic Polythiazole Cyclopeptide from a 60 L Scale Fermentation of the Deep Sea-Derived Marinactinospora thermotolerans SCSIO 00652.JOURNAL OF NATURAL PRODUCTS,75(12),2251-2255. |
| MLA | Chen, YC,et al."Marthiapeptide A, an Anti-infective and Cytotoxic Polythiazole Cyclopeptide from a 60 L Scale Fermentation of the Deep Sea-Derived Marinactinospora thermotolerans SCSIO 00652".JOURNAL OF NATURAL PRODUCTS 75.12(2012):2251-2255. |
入库方式： OAI收割
来源：南海海洋研究所
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