Cytotoxic Dihydrothiophene-Condensed Chromones from Marine-Derived Fungus Penicillium oxalicum
文献类型：期刊论文
| 作者 | Sun, YL; Zhang, XY; Liu, KS; He, F; shuhuaqi@scsio.ac.cn; Qi, SH; Xu, XY; Nong, XH; Wang, YF; Bao, J |
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2012 |
| 卷号 | 78期号:18页码:1957-1961 |
| 关键词 | Penicillium Oxalicum Scsgaf 0023 Meripilaceae Family Dihydrothiophene-condensed Chromone Cytotoxicity |
| ISSN号 | 0032-0943 |
| 英文摘要 | Two new dihydrothiophene-condensed chromones and a new natural chromone, namely oxalicumones A-C (1-3), respectively, were isolated from a culture broth of a marine-derived fungus Penicillium oxalicum SCSGAF 0023, Meripilaceae family. The structures of 1-3 and acetylated derivatives of 1 (4-7) were elucidated on the basis of spectroscopic methods and chemical reactions. The absolute configuration of 1 was established by using the modified Mosher ester method and circular dichroism data of in situ formed [Rh-2(OCOCF3)(4)] and [Mo-2(OAc)(4)] complexes. (R)-MTPA ester of 1 showed cytotoxicity against A375, SW-620, and HeLa carcinoma cell lines with IC50 values of 8.9, 7.8, and 18.4 mu M, respectively. Compound 1 displayed cytotoxicity against A375 and SW-620 cell lines with IC50 values of 11.7 and 22.6 mu M, respectively. The structure-biological activity relationship of 1 is discussed. |
| 学科主题 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 资助项目 | LMB |
| 语种 | 英语 |
| WOS记录号 | WOS:000312554100011 |
| 公开日期 | 2013-08-28 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/9738]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 通讯作者 | shuhuaqi@scsio.ac.cn |
| 推荐引用方式 GB/T 7714 | Sun, YL,Zhang, XY,Liu, KS,et al. Cytotoxic Dihydrothiophene-Condensed Chromones from Marine-Derived Fungus Penicillium oxalicum[J]. PLANTA MEDICA,2012,78(18):1957-1961. |
| APA | Sun, YL.,Zhang, XY.,Liu, KS.,He, F.,shuhuaqi@scsio.ac.cn.,...&Bao, J.(2012).Cytotoxic Dihydrothiophene-Condensed Chromones from Marine-Derived Fungus Penicillium oxalicum.PLANTA MEDICA,78(18),1957-1961. |
| MLA | Sun, YL,et al."Cytotoxic Dihydrothiophene-Condensed Chromones from Marine-Derived Fungus Penicillium oxalicum".PLANTA MEDICA 78.18(2012):1957-1961. |
入库方式： OAI收割
来源：南海海洋研究所
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