Pseudolaridimers A and B, Hetero-Cycloartane-Labdane Diels-Alder Adducts from the Cone of Pseudolarix amabilis
文献类型：期刊论文
| 作者 | Lu, L; wdzhangy@hotmail.com; Yuan, H; Shen, YH; Kong, DY; Li, B; shenyunheng9217018@yahoo.com.cn; Shan, L; Li, HL; Ye, J |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2012 |
| 卷号 | 14期号:21页码:5432-5435 |
| ISSN号 | 1523-7060 |
| 英文摘要 | Pseudolaridimers A (1) and B (2), two unprecedented heterodimers formed via a [4 + 2] Diels - Alder cycloaddition between a cycloartane triterpenoid unit and a labdane diterpenoid unit, were isolated from the cones of Pseudolarix amabilis. Their structures were established by extensive analysis of HRESIMS and NMR spectra. The absolute configuration of 1 was determined by single crystal X-ray diffraction (Cu K-alpha) of its methyl esterified derivative. Pseudolaridimer A (1) showed strong cytotoxicity against HCT116, ZR-75-30, and HL-60 human tumor cell lines, with IC50 values 9.62, 7.84, 8.29 mu g/mL, respectively. Pseudolaridimer B (2) only exhibited potent inhibition against the HL-60 cell line with an IC50 value of 7.50 mu g/mL. |
| 学科主题 | Chemistry, Organic |
| 资助项目 | LMB |
| 语种 | 英语 |
| WOS记录号 | WOS:000311245600013 |
| 公开日期 | 2013-08-28 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/9746]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 通讯作者 | wdzhangy@hotmail.com; shenyunheng9217018@yahoo.com.cn |
| 推荐引用方式 GB/T 7714 | Lu, L,wdzhangy@hotmail.com,Yuan, H,et al. Pseudolaridimers A and B, Hetero-Cycloartane-Labdane Diels-Alder Adducts from the Cone of Pseudolarix amabilis[J]. ORGANIC LETTERS,2012,14(21):5432-5435. |
| APA | Lu, L.,wdzhangy@hotmail.com.,Yuan, H.,Shen, YH.,Kong, DY.,...&Yue, RC.(2012).Pseudolaridimers A and B, Hetero-Cycloartane-Labdane Diels-Alder Adducts from the Cone of Pseudolarix amabilis.ORGANIC LETTERS,14(21),5432-5435. |
| MLA | Lu, L,et al."Pseudolaridimers A and B, Hetero-Cycloartane-Labdane Diels-Alder Adducts from the Cone of Pseudolarix amabilis".ORGANIC LETTERS 14.21(2012):5432-5435. |
入库方式： OAI收割
来源：南海海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。