N-N-Coupled Indolo-sesquiterpene Atropo-Diastereomers from a Marine-Derived Actinomycete
文献类型：期刊论文
| 作者 | Zhang, CS; Zhang, QB; Mandi, A; Li, SM; Chen, YC; Zhang, WJ; Tian, XP; Zhang, HB; Li, HX; Zhang, WM |
| 刊名 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2012 |
| 期号 | 27页码:5256-5262 |
| 关键词 | Natural Products Terpenoids Xiamycin Atropisomerism Configuration Determination Density Functional Calculations |
| ISSN号 | 1434-193X |
| 英文摘要 | Four new indolo-sesquiterpenes dixiamycins A (1) and B (2), oxiamycin (3), and chloroxiamycin (4) were isolated from a marine-derived Actinomycete and characterized, together with the known compound xiamycin A (5). Dixiamycins A (1) and B (2) are the first examples of atropisomerism of naturally occurring N-N-coupled atropo-diastereomers, with a dimeric indolo-sesquiterpene skeleton and a stereogenic N-N axis between sp3-hybridized nitrogen atoms. Solution TDDFT ECD calculations were utilized to ascertain the axial chirality of 1 and 2, and rotational barriers and transitions states of the inversion were calculated. Oxiamycin (3) contains a seven-membered 2,3,4,5-tetrahydrooxepine ring. The two dimeric compounds 1 and 2 showed better antibacterial activities than the monomers 35. |
| 学科主题 | Chemistry, Organic |
| 资助项目 | LMB |
| 语种 | 英语 |
| WOS记录号 | WOS:000308580800016 |
| 公开日期 | 2013-08-28 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/9818]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 通讯作者 | kurtan.tibor@science.unideb.hu; czhang2006@gmail.com |
| 推荐引用方式 GB/T 7714 | Zhang, CS,Zhang, QB,Mandi, A,et al. N-N-Coupled Indolo-sesquiterpene Atropo-Diastereomers from a Marine-Derived Actinomycete[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2012(27):5256-5262. |
| APA | Zhang, CS.,Zhang, QB.,Mandi, A.,Li, SM.,Chen, YC.,...&czhang2006@gmail.com.(2012).N-N-Coupled Indolo-sesquiterpene Atropo-Diastereomers from a Marine-Derived Actinomycete.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(27),5256-5262. |
| MLA | Zhang, CS,et al."N-N-Coupled Indolo-sesquiterpene Atropo-Diastereomers from a Marine-Derived Actinomycete".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .27(2012):5256-5262. |
入库方式： OAI收割
来源：南海海洋研究所
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