Identification of Caerulomycin A Gene Cluster Implicates a Tailoring Amidohydrolase
文献类型：期刊论文
| 作者 | Ju, JH; Zhu, WM; Zhang, CS; czhang2006@gmail.com; weimingzhu@ouc.edu.cn; Zhu, YG; Fu, P; Lin, QH; Zhang, GT; Zhang, HB |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2012 |
| 卷号 | 14期号:11页码:2666-2669 |
| ISSN号 | 1523-7060 |
| 英文摘要 | The biosynthetic gene cluster for caerulomycin A (1) was cloned and characterized from the marine actinomycete Actinoalloteichus cyanogriseus WH1-2216-6, which revealed an unusual hybrid polyketide synthase (PKS)/nonribosomal peptide synthetase (NRPS) system. The crmL disruption mutant accumulated caerulomycin L (2) with an extended L-leucine at C-7, implicating an amidohydrolase activity for CrmL. The leucine-removing activity was confirmed for crude CrmL enzymes. Heterologous expression of the 1 gene cluster led to 1 production in Streptomyces coelicolor. |
| 学科主题 | Chemistry, Organic |
| 资助项目 | LMB |
| 语种 | 英语 |
| WOS记录号 | WOS:000304682700004 |
| 公开日期 | 2013-08-28 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/9888]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 通讯作者 | czhang2006@gmail.com; weimingzhu@ouc.edu.cn |
| 推荐引用方式 GB/T 7714 | Ju, JH,Zhu, WM,Zhang, CS,et al. Identification of Caerulomycin A Gene Cluster Implicates a Tailoring Amidohydrolase[J]. ORGANIC LETTERS,2012,14(11):2666-2669. |
| APA | Ju, JH.,Zhu, WM.,Zhang, CS.,czhang2006@gmail.com.,weimingzhu@ouc.edu.cn.,...&Li, SM.(2012).Identification of Caerulomycin A Gene Cluster Implicates a Tailoring Amidohydrolase.ORGANIC LETTERS,14(11),2666-2669. |
| MLA | Ju, JH,et al."Identification of Caerulomycin A Gene Cluster Implicates a Tailoring Amidohydrolase".ORGANIC LETTERS 14.11(2012):2666-2669. |
入库方式： OAI收割
来源：南海海洋研究所
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