Antiproliferative activity of Goldfussia psilostachys ethanolic extract on K562 leukemia cells
文献类型：期刊论文
| 作者 | Gao, XP ; Zhang, GL ; Zhou, M ; Luo, DX ; Li, BG |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2004 |
| 卷号 | 75期号:7_8页码:639_644 |
| 关键词 | Goldfussia psilostachys cell growth inhibition cell cycle antimitosis tubulin polymerization K562 cell line |
| ISSN号 | 0367-326X |
| 产权排序 | 2 |
| 通讯作者 | Zhang, GL, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China. |
| 中文摘要 | A dose-dependent and significant (P<0.01) antiproliferative effect of Goldfussia psilostachys ethanolic extract was observed on K562 cells. The IC50 is ca. 0.5 mug/ml. The extract markedly increases the proportion of cell in G2/M phases and decreases the population of cells in G0/G1 phases. Moreover, the antimitotic effect is correlated with polymerization of microtubule assembly. These results indicate that G. psilostachys ethanolic extract inhibits the proliferation of K562 cells and disrupts the normal dynamic of microtubules during mitosis. (C) 2004 Elsevier B.V All rights reserved. |
| 学科主题 | Chemistry, Medicinal; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000225737900004 |
| 公开日期 | 2011-07-08 |
| 源URL | [http://210.75.237.14/handle/351003/17487]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Gao, XP,Zhang, GL,Zhou, M,et al. Antiproliferative activity of Goldfussia psilostachys ethanolic extract on K562 leukemia cells[J]. FITOTERAPIA,2004,75(7_8):639_644. |
| APA | Gao, XP,Zhang, GL,Zhou, M,Luo, DX,&Li, BG.(2004).Antiproliferative activity of Goldfussia psilostachys ethanolic extract on K562 leukemia cells.FITOTERAPIA,75(7_8),639_644. |
| MLA | Gao, XP,et al."Antiproliferative activity of Goldfussia psilostachys ethanolic extract on K562 leukemia cells".FITOTERAPIA 75.7_8(2004):639_644. |
入库方式： OAI收割
来源：成都生物研究所
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