The effects of diketopiperazines from Callyspongia sp on release of cytokines and chemokines in cultured J774A.1 macrophages
文献类型：期刊论文
| 作者 | Lan, XP; jiaaiqun@gmail.com; yonghongliu@scsio.ac.cn; Jia, AQ; Liu, YH; Chen, JH |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2012 |
| 卷号 | 22期号:9页码:3177-3180 |
| 关键词 | Cytokine Chemokine Diketopiperazines J774a.1 Macrophage Structure-activity Relationships |
| ISSN号 | 0960-894X |
| 英文摘要 | Diketopiperazines (DKPs) are a class of secondary metabolites that result from peptide bonds between two amino acids to form a lactam. Due to their rigid structure, chiral nature, and varied side chains, DKPs have been of research interest for their diverse bioactivities. However, little is known about whether DPKs stimulate the release of cytokine and chemokines in macrophage cells. The present aim was to study the effect of DKPs firstly isolated from sponge Callyspongia sp. on the release of several cytokines in murine macrophage-like cell line J774A.1 after stimulation in vitro, and their potential structure-activity relationship of five natural DKPs on four representative cytokines, interferon-gamma (IFN-gamma), pro-inflammatory (tumor necrosis factor, TNF-alpha), anti-inflammatory cytokine (interleukin-10, IL-10), and chemokine (monocyte chemoattractant protein-1, MCP-1). Results suggested that these five DKPs, especially DKP 1 bearing 3-hydroxyl-L-proline (L-Hyp), might be useful as a promising macrophage cytokines stimulator. (C) 2012 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry, Medicinal ; Chemistry, Organic |
| 资助项目 | LMB |
| 语种 | 英语 |
| WOS记录号 | WOS:000302964300027 |
| 公开日期 | 2013-08-28 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/9926]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 通讯作者 | jiaaiqun@gmail.com; yonghongliu@scsio.ac.cn |
| 推荐引用方式 GB/T 7714 | Lan, XP,jiaaiqun@gmail.com,yonghongliu@scsio.ac.cn,et al. The effects of diketopiperazines from Callyspongia sp on release of cytokines and chemokines in cultured J774A.1 macrophages[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(9):3177-3180. |
| APA | Lan, XP,jiaaiqun@gmail.com,yonghongliu@scsio.ac.cn,Jia, AQ,Liu, YH,&Chen, JH.(2012).The effects of diketopiperazines from Callyspongia sp on release of cytokines and chemokines in cultured J774A.1 macrophages.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(9),3177-3180. |
| MLA | Lan, XP,et al."The effects of diketopiperazines from Callyspongia sp on release of cytokines and chemokines in cultured J774A.1 macrophages".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.9(2012):3177-3180. |
入库方式： OAI收割
来源：南海海洋研究所
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