Antifouling and cytotoxic constituents from the South China Sea sponge Acanthella cavernosa
文献类型：期刊论文
| 作者 | frank-lin67@126.com; Jiao, WH; Wang, RP; Peng, Y; Qi, SH; Xu, Y; Li, N; Song, SJ; Chen, WS; Lin, HW |
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2012 |
| 卷号 | 68期号:13页码:2876-2883 |
| 关键词 | Acanthella Cavernosa Kalihinol X-ray Diffraction Analysis Antifouling Cytotoxic Absolute Configuration |
| ISSN号 | 0040-4020 |
| 英文摘要 | A bioassay-guided chemical investigation of the South China Sea sponge Acanthella cavemosa resulted in the isolation of eight new diterpenoids, kalihinols M-T (1-8), together with seven known analogues (9-15). These compounds featured a trans-decalin ring bearing a tetrahydrofuran or a tetrahydropyran ring at C-7. Compounds 1 and 2, with a formamide functionality beared at C-4, extended the structure breadth of this diterpenoid family. The absolute stereostructures of 1-14 were determined by a combination of 2D NMR and CD spectroscopic analysis and single crystal X-ray diffraction. Compounds 1 and 2 were confirmed to have the configurations of 4S, 55, whereas 3-14 were determined as 4R, 5R. Compounds 3-14 displayed significant antifouling activity against the barnacle Balanus amphitrite larvae, and the cytotoxic activities of 3-14 were evaluated against the H1299, A549, PC3, CT-26, and HCT-116 cancer cell lines. (C) 2012 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry, Organic |
| 资助项目 | LMB |
| 语种 | 英语 |
| WOS记录号 | WOS:000301964700016 |
| 公开日期 | 2013-08-28 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/9952]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 通讯作者 | frank-lin67@126.com; songsj99@yahoo.com.cn |
| 推荐引用方式 GB/T 7714 | frank-lin67@126.com,Jiao, WH,Wang, RP,et al. Antifouling and cytotoxic constituents from the South China Sea sponge Acanthella cavernosa[J]. TETRAHEDRON,2012,68(13):2876-2883. |
| APA | frank-lin67@126.com.,Jiao, WH.,Wang, RP.,Peng, Y.,Qi, SH.,...&songsj99@yahoo.com.cn.(2012).Antifouling and cytotoxic constituents from the South China Sea sponge Acanthella cavernosa.TETRAHEDRON,68(13),2876-2883. |
| MLA | frank-lin67@126.com,et al."Antifouling and cytotoxic constituents from the South China Sea sponge Acanthella cavernosa".TETRAHEDRON 68.13(2012):2876-2883. |
入库方式： OAI收割
来源：南海海洋研究所
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