Enantioselective cyanosilylation of ketones catalyzed by double-activation catalysts with N-oxides
文献类型：期刊论文
| 作者 | Chen, FX ; Qin, B ; Feng, XM ; Zhang, GL ; Jiang, YZ |
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2004 |
| 卷号 | 60期号:46页码:10449_10460 |
| 关键词 | asymmetric catalysis cyanohydrin cyanosilylation double-activation ketone N-oxide |
| ISSN号 | 0040-4020 |
| 产权排序 | 2 |
| 通讯作者 | Feng, XM, Sichuan Univ, Minist Educ, Coll Chem, Key LGreen Chem & Technol, Chengdu 610064, Peoples R China. |
| 中文摘要 | Enantioselective addition of trimethylsilyl cyanide to ketones by a catalytic double-activation method is described. By combinatorially using 2.0 mol% of a chiral salen-titanium complex and 1.0 mol% of an achiral tertiary amine N-oxide, aromatic, aliphatic and alpha,beta-unsaturated ketones are converted into corresponding cyanohydrin trimethylsilyl ethers with 50-93% yield and 59-86% ee. The effects of ligand structure, catalyst loading and substrate concentration, solvents, the nature of Lewis base, counter ion and other additives, temperature, and substrate structure on the enantioselectivity are discussed. Three possible paths to achieve the asymmetric version of double-activation catalysis and two independent examples of it are proposed. (C) 2004 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry, Organic |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000224632300008 |
| 公开日期 | 2011-07-08 |
| 源URL | [http://210.75.237.14/handle/351003/17505]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Chen, FX,Qin, B,Feng, XM,et al. Enantioselective cyanosilylation of ketones catalyzed by double-activation catalysts with N-oxides[J]. TETRAHEDRON,2004,60(46):10449_10460. |
| APA | Chen, FX,Qin, B,Feng, XM,Zhang, GL,&Jiang, YZ.(2004).Enantioselective cyanosilylation of ketones catalyzed by double-activation catalysts with N-oxides.TETRAHEDRON,60(46),10449_10460. |
| MLA | Chen, FX,et al."Enantioselective cyanosilylation of ketones catalyzed by double-activation catalysts with N-oxides".TETRAHEDRON 60.46(2004):10449_10460. |
入库方式： OAI收割
来源：成都生物研究所
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