Characterization and comparative analyses of zebrafish intelectins: Highly conserved sequences, diversified structures and functions
文献类型：期刊论文
| 作者 | Lin, B; Cao, Z; Su, P; Zhang, HB; Li, MZ; Lin, YQ; Zhao, DZ; Shen, Y; Jing, CF; Chen, SW |
| 刊名 | FISH & SHELLFISH IMMUNOLOGY
 |
| 出版日期 | 2009 |
| 卷号 | 26期号:3页码:396-405 |
| 关键词 | Zebrafish Intelectin Lectin Evolution Innate Immunity Expression Pattern |
| ISSN号 | 1050-4648 |
| 英文摘要 | Intelectin family, also called the X-lectin family, is a newly discovered gene family involved in development and innate immunity. However, no research was carried out for this gene family in the model organism zebrafish. Here we present the first characterization of seven zebrafish intelectins (zINTLs) and the first systematic comparative analysis of intelectins from various species in order to provide some clues to the function and evolution of this gene family. We examined the expression patterns of zINTLs in various development stages, normal adults, and Aeromonas salmonicida infected adults. Results showed that zINTL1-3 were highly expressed in one or several adult tissues. zlNTL4-7, however, were expressed at quite low levels both in adults and various development stages, and some of them showed relaxation of functional constrains as revealed by K-a/K-s calculation. Of the seven zINTLs, zINTL3 was expressed predominantly in the liver and highly up-regulated upon infection, suggesting its important roles in immunity. Based on the characterization of zebrafish intelectins, we then conducted a systematic survey of intelectin members in various species and made Comparative analyses. We found out that intelectin family may be a deuterostome specific gene family; and their expression patterns, quaternary structures and glycosylations vary considerably among various species, though their sequences are highly conserved. Moreover, these varied features have evolved multiple times independently in different species, resulting in species-specific protein structures and expression patterns. (C) 2008 Elsevier Ltd. All rights reserved. |
| 学科主题 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| URL标识 | 查看原文 |
| 资助项目 | 海洋生物 |
| 公开日期 | 2011-07-03 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/5398]  |
| 专题 | 南海海洋研究所_海洋生物 |
| 通讯作者 | lssxal@mail.sysu.edu.cn |
| 推荐引用方式 GB/T 7714 | Lin, B,Cao, Z,Su, P,et al. Characterization and comparative analyses of zebrafish intelectins: Highly conserved sequences, diversified structures and functions[J]. FISH & SHELLFISH IMMUNOLOGY,2009,26(3):396-405. |
| APA | Lin, B.,Cao, Z.,Su, P.,Zhang, HB.,Li, MZ.,...&lssxal@mail.sysu.edu.cn.(2009).Characterization and comparative analyses of zebrafish intelectins: Highly conserved sequences, diversified structures and functions.FISH & SHELLFISH IMMUNOLOGY,26(3),396-405. |
| MLA | Lin, B,et al."Characterization and comparative analyses of zebrafish intelectins: Highly conserved sequences, diversified structures and functions".FISH & SHELLFISH IMMUNOLOGY 26.3(2009):396-405. |
入库方式： OAI收割
来源：南海海洋研究所
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