The effect of a micronutrient powder home fortification program on anemia and cognitive outcomes among young children in rural China: a cluster randomized trial
文献类型：期刊论文
| 作者 | Luo, Renfu1 ; Yue, Ai2; Zhou, Huan3; Shi, Yaojiang2; Zhang, Linxiu4; Martorell, Reynaldo5; Medina, Alexis6; Rozelle, Scott6; Sylvia, Sean7
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| 刊名 | BMC PUBLIC HEALTH
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| 出版日期 | 2017-09-25 |
| 卷号 | 17页码:16 |
| 关键词 | Micronutrient supplementation Anemia Cognition Early childhood |
| ISSN号 | 1471-2458 |
| DOI | 10.1186/s12889-017-4755-0 |
| 通讯作者 | Yue, Ai(yueai@163.com) |
| 英文摘要 | Background: Anemia early in life has been associated with delayed cognitive and motor development. The WHO recommends home fortification using multiple micronutrient powders (MNPs) containing iron as a strategy to address anemia in children under two. We evaluated the effects of a program freely distributing MNP sachets to caregivers of infants in rural China. Methods: We conducted a cluster-randomized controlled trial in Shaanxi province, enrolling all children aged 6-11 months in target villages. Following a baseline survey, investigators randomly assigned each village/cluster to a control or treatment group. In the treatment group, caregivers were instructed to give MNPs daily. Follow-up was after 6, 12, and 18 months of intervention. Primary outcomes were hemoglobin concentrations and scores on the Bayley Scales of Infant Development. Results: One thousand, eight hundred and-two eligible children and their caregivers were enrolled. At baseline 48% (870) of children were anemic and 29% (529) were developmentally delayed. Six hundred and-ten children (117 villages) were assigned to the control group and 1192 children (234 villages) were assigned to the treatment group. Assignment to the treatment group was associated with an improvement in hemoglobin levels (marginal effect 1.77 g/L, 95% CI 0.017-3.520, p-value = 0.048) and cognitive development (marginal effect 2.23 points, 95% CI 0.061-4.399, p-value = 0.044) after 6 months but not thereafter. There were no significant effects on motor development. Zero effects after the first 6 months were not due to low compliance, low statistical power, or changes in feeding behavior. Hemoglobin concentrations improved in both the treatment and control groups over the course of the study; however, 22% (325) of children remained anemic at endline, and 48% (721) were cognitively delayed. Conclusions: Providing caregivers with MNP sachets modestly hastened improvement in hemoglobin levels that was occurring absent intervention; however, this improvement did not translate into improved developmental outcomes at endline. |
| WOS关键词 | IRON-DEFICIENCY ANEMIA ; DEVELOPMENTAL TEST-PERFORMANCE ; MIDDLE-INCOME COUNTRIES ; EARLY-CHILDHOOD ; MENTAL-DEVELOPMENT ; MOTOR DEVELOPMENT ; SHAANXI PROVINCE ; WESTERN CHINA ; INFANTS ; SUPPLEMENTATION |
| 资助项目 | International Initiative for Impact Evaluation (3ie) ; National Natural Science Foundation of China[71473239] ; National Natural Science Foundation of China[71703083] ; UBS Optimus Foundation ; China Medical Board ; Bank of East Asia ; Huaqiao Foundation ; Bill & Melinda Gates Foundation-HBGDki Initiative ; Noblesse ; H.J. Heinz Company Foundation |
| WOS研究方向 | Public, Environmental & Occupational Health |
| 语种 | 英语 |
| WOS记录号 | WOS:000412110200002 |
| 出版者 | BIOMED CENTRAL LTD |
| 资助机构 | International Initiative for Impact Evaluation (3ie) ; National Natural Science Foundation of China ; UBS Optimus Foundation ; China Medical Board ; Bank of East Asia ; Huaqiao Foundation ; Bill & Melinda Gates Foundation-HBGDki Initiative ; Noblesse ; H.J. Heinz Company Foundation |
| 源URL | [http://ir.igsnrr.ac.cn/handle/311030/62183]  |
| 专题 | 中国科学院地理科学与资源研究所 |
| 通讯作者 | Yue, Ai |
| 作者单位 | 1.Peking Univ, Sch Adv Agr Sci, China Ctr Agr Policy, Beijing, Peoples R China 2.Shaanxi Normal Univ, Ctr Expt Econ Educ, 620 Changan Rd West, Xian 710119, Shaanxi, Peoples R China 3.Sichuan Univ, West China Sch Publ Hlth, Chengdu, Sichuan, Peoples R China 4.Chinese Acad Sci, Ctr Chinese Agr Policy, Beijing, Peoples R China 5.Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA 6.Stanford Univ, Freeman Spogli Inst Int Studies, Stanford, CA 94305 USA 7.Univ North Carolina Chapel Hill, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA |
| 推荐引用方式 GB/T 7714 | Luo, Renfu,Yue, Ai,Zhou, Huan,et al. The effect of a micronutrient powder home fortification program on anemia and cognitive outcomes among young children in rural China: a cluster randomized trial[J]. BMC PUBLIC HEALTH,2017,17:16. |
| APA | Luo, Renfu.,Yue, Ai.,Zhou, Huan.,Shi, Yaojiang.,Zhang, Linxiu.,...&Sylvia, Sean.(2017).The effect of a micronutrient powder home fortification program on anemia and cognitive outcomes among young children in rural China: a cluster randomized trial.BMC PUBLIC HEALTH,17,16. |
| MLA | Luo, Renfu,et al."The effect of a micronutrient powder home fortification program on anemia and cognitive outcomes among young children in rural China: a cluster randomized trial".BMC PUBLIC HEALTH 17(2017):16. |
入库方式： OAI收割
来源：地理科学与资源研究所
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