Quantitative analyses of indoloquinazoline alkaloids in Fructus Evodiae by high-performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry
文献类型：期刊论文
| 作者 | Zhou, Y ; Li, SH ; Jiang, RW ; Cai, M ; Liu, X ; Ding, LS ; Xu, HX ; But, PPH ; Shaw, PC |
| 刊名 | RAPID COMMUNICATIONS IN MASS SPECTROMETRY
 |
| 出版日期 | 2006 |
| 卷号 | 20期号:20页码:3111_3118 |
| ISSN号 | 0951-4198 |
| 产权排序 | 2 |
| 通讯作者 | But, PPH, Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China. |
| 中文摘要 | Fructus Evodiae (Wuzhuyu), the fruits of Evodia rutaecarpa and related varieties, is widely used in traditional Chinese medicine. The bioactive constituents include the indoloquinazoline alkaloids rutaecarpine, evodiamine and dehydroevodiamine. A new assay based on high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry (HPLC/UV/APCI-MS/MS) was developed for the measurement of the indoloquinazoline alkaloids in commercial Fructus Evodiae products. Initially, the MS/MS fragmentation pathways of indoloquinazoline alkaloids were investigated to identify fragment ions that might be useful for the sensitive and selective detection of trace indoloquinazoline alkaloids during LC/MS/MS. Then, quantitative MS analysis of five indoloquinazoline alkaloids in 12 commercial Fructus Evodiae products from different geographical sources was performed. Analyte recovery was in the range of 97.5-105.3% for all with relative standard deviations (RSDs) below 6%, the intra-assay and inter-assay RSDs were less than 7%, and good linear relationships were shown with correlation coefficients for the analytes exceeding 0.999. Therefore, this LC/MS/MS assay facilitated the rapid quantitative analysis of rutaecarpine, evodiamine, evodiamide, 14-formyldihydrorutaecarpine and dehydroevodiamine in 12 commercial Fructus Evodiae products with excellent recovery, repeatability, accuracy and sensitivity. This method is simple and specific and can be used for identification and quality control of this traditional Chinese remedy. Copyright (c) 2006 John Wiley & Sons, Ltd. |
| 学科主题 | Biochemical Research Methods; Chemistry, Analytical; Spectroscopy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000241332500014 |
| 公开日期 | 2011-07-08 |
| 源URL | [http://210.75.237.14/handle/351003/17825]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Zhou, Y,Li, SH,Jiang, RW,et al. Quantitative analyses of indoloquinazoline alkaloids in Fructus Evodiae by high-performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry[J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2006,20(20):3111_3118. |
| APA | Zhou, Y.,Li, SH.,Jiang, RW.,Cai, M.,Liu, X.,...&Shaw, PC.(2006).Quantitative analyses of indoloquinazoline alkaloids in Fructus Evodiae by high-performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry.RAPID COMMUNICATIONS IN MASS SPECTROMETRY,20(20),3111_3118. |
| MLA | Zhou, Y,et al."Quantitative analyses of indoloquinazoline alkaloids in Fructus Evodiae by high-performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry".RAPID COMMUNICATIONS IN MASS SPECTROMETRY 20.20(2006):3111_3118. |
入库方式： OAI收割
来源：成都生物研究所
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