Genes involved in the anti-cancer effect of a potent new compound boehmeriasin A on breast cancer cell
文献类型：期刊论文
| 作者 | Wei, HY ; Yan, JF ; Liu, JY ; Luo, DX ; Zhang, J ; Gao, XP |
| 刊名 | JOURNAL OF MEDICINAL PLANTS RESEARCH
 |
| 出版日期 | 2009 |
| 卷号 | 3期号:1页码:35_44 |
| 关键词 | Boehmeriasin A anti-cancer SSH gene chip |
| ISSN号 | 1996-0875 |
| 产权排序 | 3 |
| 通讯作者 | Yan, JF, Di Ao Pharmaceut Grp, Inst Mat Med, Chengdu, Peoples R China. |
| 中文摘要 | Boehmeriasin A is a new compound showing good anticancer effect on breast cancer cell: MDA-MB-231 in vitro. The anti-cancer effect of it was revealed by gene chip and suppression subtractive hybridization (SSH). Totally, there are 328 genes of differential expression obtained from gene chip analysis. Two subtractive libraries were constructed and 163 EST cDNA clones were screened out. RTPCR, virtual Northern, Northern and Western blot were applied to confirm the result. In conclusion, Boehmeriasin A lowered the expression of genes involved in apoptosis, while promoted expression of some differentiation related genes. This study supplies further evidence that boehmeriasin A inhibit the growth of breast cancer cells through inducing differentiation. In addition, the compound may lead to cell growth arrested via restraining the expression of genes related to cell proliferation and cell cycle regulation. Expression of genes involved in TGF-beta 1 signal transduction were varied, suggesting the effect of boehmeriasin A is closely associated with TGF-beta 1 pathway. |
| 学科主题 | Chemistry, Medicinal |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000262157400007 |
| 公开日期 | 2011-07-08 |
| 源URL | [http://210.75.237.14/handle/351003/18247]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Wei, HY,Yan, JF,Liu, JY,et al. Genes involved in the anti-cancer effect of a potent new compound boehmeriasin A on breast cancer cell[J]. JOURNAL OF MEDICINAL PLANTS RESEARCH,2009,3(1):35_44. |
| APA | Wei, HY,Yan, JF,Liu, JY,Luo, DX,Zhang, J,&Gao, XP.(2009).Genes involved in the anti-cancer effect of a potent new compound boehmeriasin A on breast cancer cell.JOURNAL OF MEDICINAL PLANTS RESEARCH,3(1),35_44. |
| MLA | Wei, HY,et al."Genes involved in the anti-cancer effect of a potent new compound boehmeriasin A on breast cancer cell".JOURNAL OF MEDICINAL PLANTS RESEARCH 3.1(2009):35_44. |
入库方式： OAI收割
来源：成都生物研究所
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