Crosslinking of viral nanoparticles with "clickable" fluorescent crosslinkers at the interface
文献类型：期刊论文
| 作者 | Kaur, Gagandeep ; Zhan WenHai ; Wang Chao ; Barnhill, Hannah ; Tian He ; Wang Qian |
| 刊名 | SCIENCE CHINA-CHEMISTRY
 |
| 出版日期 | 2010 |
| 卷号 | 53期号:6页码:1287-1293 |
| 关键词 | pickering emulsion crosslinking nanoparticles CuAAC reaction click chemistry interfacial assembly |
| ISSN号 | 1674-7291 |
| 产权排序 | 3 |
| 通讯作者 | Tian, H, E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China |
| 中文摘要 | Cu (I) catalyzed alkyne-azide cycloaddition (CuAAC) reaction, a typical "click" reaction, is one of the modular synthetic approaches which has been broadly used in various organic syntheses, medicinal chemistry, materials development and bioconjugation applications. We have for the first time synthesized two dialkyne derivatized fluorescent crosslinkers which could be applied to crosslink two biomolecules using CuAAC reaction. Turnip yellow mosaic virus, a plant virus with unique structural and chemical properties, was used as a prototypical scaffold to form a 2D single layer at the interface of two immiscible liquids and crosslinked with these two linkers by the CuAAC reaction. Upon crosslinking, the fluorescence of both linkers diminished, likely due to the distortion of the polymethylene backbone, which therefore could be used to indicate the completion of the reaction. |
| 学科主题 | Chemistry, Multidisciplinary |
| 收录类别 | SCI |
| 资助信息 | US NSF [CHE-0748690]; US DoD-ARO [W911NF-09-1-0236]; W. M. Keck Foundation ; Camille Dreyfus Teacher-Scholarship ; Alfred P. Sloan Foundation ; National Natural Science Foundation of China [50673025]; National Basic Research 973 Program [2006CB806200]; US DoE |
| 语种 | 英语 |
| WOS记录号 | WOS:000279240100009 |
| 公开日期 | 2011-07-08 |
| 源URL | [http://210.75.237.14/handle/351003/18381]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Kaur, Gagandeep,Zhan WenHai,Wang Chao,et al. Crosslinking of viral nanoparticles with "clickable" fluorescent crosslinkers at the interface[J]. SCIENCE CHINA-CHEMISTRY,2010,53(6):1287-1293. |
| APA | Kaur, Gagandeep,Zhan WenHai,Wang Chao,Barnhill, Hannah,Tian He,&Wang Qian.(2010).Crosslinking of viral nanoparticles with "clickable" fluorescent crosslinkers at the interface.SCIENCE CHINA-CHEMISTRY,53(6),1287-1293. |
| MLA | Kaur, Gagandeep,et al."Crosslinking of viral nanoparticles with "clickable" fluorescent crosslinkers at the interface".SCIENCE CHINA-CHEMISTRY 53.6(2010):1287-1293. |
入库方式： OAI收割
来源：成都生物研究所
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