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Interaction between tryptophan-vanillin Schiff base and herring sperm DNA

文献类型：期刊论文

作者Zhang, Yan ; Wang, Xingming ; Ding, Lisheng
刊名JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
出版日期2010
卷号75期号:9页码:1191-1201
关键词vanillin L-tryptophan Schiff base herring sperm DNA interaction
ISSN号0352-5139
产权排序2
通讯作者Wang, XM, SW Univ Sci & Technol, Sch Mat Sci & Engn, Dept Chem, Mianyang 621010, Peoples R China
中文摘要The interaction of the Schiff base (K[HL]) with herring sperm DNA was studied by UV-Vis absorption, fluorescence and viscosity methods in a physiological pH environment (pH 7.40), where the Schiff base was derived from vanillin and L-tryptophan. A binding ratio of nK[HL]:nDNA = 5:1 and an apparent molar absorption coefficient of (K [HL] DNA) = 4.98x10(5) L mol(-1) cm(-1) were confirmed by the mole ratio method. The binding constants of K-B(circle minus)(301 K) = 1.94 x 10(5) L mol(-1) and K-B(circle minus) (310 K) = 1.09 x 10(5) L.mol(-1) were obtained by the double reciprocal method. Thermodynamic parameters suggest that the interaction between K[HL] and DNA is driven mainly by enthalpy. Combined with Scatchard methods and viscosity methods, the results indicate the presence of intercalation and groove binding between K[HL] and DNA.
学科主题Chemistry, Multidisciplinary
收录类别SCI
资助信息National Natural Science Foundation of China [30572254]; Postgraduate Innovation Foundation of the Southwest University of Science and Technology
语种英语
WOS记录号WOS:000283207200003
公开日期2011-07-08
源URL[http://210.75.237.14/handle/351003/18405]  
专题成都生物研究所_天然产物研究
推荐引用方式
GB/T 7714		 Zhang, Yan,Wang, Xingming,Ding, Lisheng. Interaction between tryptophan-vanillin Schiff base and herring sperm DNA[J]. JOURNAL OF THE SERBIAN CHEMICAL SOCIETY,2010,75(9):1191-1201.
APA Zhang, Yan,Wang, Xingming,&Ding, Lisheng.(2010).Interaction between tryptophan-vanillin Schiff base and herring sperm DNA.JOURNAL OF THE SERBIAN CHEMICAL SOCIETY,75(9),1191-1201.
MLA Zhang, Yan,et al."Interaction between tryptophan-vanillin Schiff base and herring sperm DNA".JOURNAL OF THE SERBIAN CHEMICAL SOCIETY 75.9(2010):1191-1201.

入库方式： OAI收割

来源：成都生物研究所

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