Developmental neurotoxicity of reserpine exposure in zebrafish larvae (Danio rerio)
文献类型:期刊论文
作者 | Wang, Shao1,2; Duan, Ming3; Guan, Kaiyu1,2; Zhou, Xianyong1,2; Zheng, Miaomiao1,2; Shi, Xulai4; Ye, Minjie1,2; Guan, Wanchun2,5; Kuver, Aarti2; Huang, Manli6,7 |
刊名 | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY |
出版日期 | 2019-09-01 |
卷号 | 223期号:1页码:115-123 |
ISSN号 | 1532-0456 |
关键词 | Reserpine Dopaminergic system Zebrafish larvae |
DOI | 10.1016/j.cbpc.2019.05.008 |
英文摘要 | Reserpine is widely used for treatment of hypertension and schizophrenia. As a specific inhibitor of monoamine transporters, reserpine is known to deplete monoamine neurotransmitters and cause decreased movement symptoms. However, how zebrafish larvae respond to reserpine treatment is not well studied. Here we show that swimming distance and average velocity are significantly reduced after reserpine exposure under various stimulatory conditions. Using liquid chromatograph mass spectrometer analysis, decreased levels of monoamines (e.g. dopamine, noradrenaline, and serotonin) were detected in reserpine-treated larvae. Moreover, reserpine treatment significantly reduced the number of dopaminergic neurons, which was identified with th (Tyrosine Hydroxylase) in situ hybridization in the preoptic area. Interestingly, dopaminergic neuron development-associated genes, such as otpa, otpb, wnt1, wnt3, wnt5 and manf; were downregulated in reserpine treated larvae. Our data indicates that 2 mg/L reserpine exposure induces dopaminergic neuron damage in the brain, demonstrating a chemical induced depression-like model in zebrafish larvae for future drug development. |
WOS关键词 | DOPAMINERGIC NEURON DEVELOPMENT ; PARKINSONS-DISEASE ; DEPRESSION ; MODEL ; MOTOR ; EXPRESSION ; MONOAMINES ; AGONIST ; RATS |
资助项目 | National Natural Science Foundation of China[81673643] ; National Natural Science Foundation of China[31501146] ; National Natural Science Foundation of China[31471269] ; Science and Technology Department of Zhejiang Province[2012C23066] ; Science and Technology Department of Zhejiang Province[LQ15C120001] ; Student Science and Technology Innovation Activity Plan of Zhejiang Province[2018R413030] ; Student Science and Technology Innovation Activity Plan of Zhejiang Province[2018R413185] ; Wenzhou Municipal Science and Technology Bureau Program[Y20170017] ; Wenzhou Municipal Science and Technology Bureau Program[Y20160195] ; Wenzhou Medical and Health Research Project[2018A09] ; Wenzhou Medical and Health Research Project[2018A10] ; Key Research Project of Zhejiang Province[2015C03040] ; Zhejiang Province Science & Technology (Laboratory Animal) Project[2017C37127] |
WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Toxicology ; Zoology |
语种 | 英语 |
出版者 | ELSEVIER SCIENCE INC |
WOS记录号 | WOS:000477686100014 |
资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Department of Zhejiang Province ; Science and Technology Department of Zhejiang Province ; Science and Technology Department of Zhejiang Province ; Science and Technology Department of Zhejiang Province ; Science and Technology Department of Zhejiang Province ; Science and Technology Department of Zhejiang Province ; Science and Technology Department of Zhejiang Province ; Science and Technology Department of Zhejiang Province ; Student Science and Technology Innovation Activity Plan of Zhejiang Province ; Student Science and Technology Innovation Activity Plan of Zhejiang Province ; Student Science and Technology Innovation Activity Plan of Zhejiang Province ; 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源URL | [http://ir.ihb.ac.cn/handle/342005/32170] |
专题 | 水生生物研究所_中科院水生所知识产出(2009年前) |
通讯作者 | Dai, Kezhi; Li, Xi |
作者单位 | 1.Wenzhou Med Univ, Affiliated Kangning Hosp, 1 Shengjin Rd, Wenzhou 325000, Zhejiang, Peoples R China 2.Wenzhou Med Univ, Sch Mental Hlth, Wenzhou 32500, Zhejiang, Peoples R China 3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China 4.Wenzhou Med Univ, Affiliated Hosp 2, Wenzhou 325000, Zhejiang, Peoples R China 5.Wenzhou Med Univ, Sch Lab Med & Life Sci, Wenzhou 325000, Zhejiang, Peoples R China 6.Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Psychiat, Hangzhou 310003, Zhejiang, Peoples R China 7.Key Lab Mental Disorder Management Zhejiang Prov, Hangzhou 310003, Zhejiang, Peoples R China 8.Yangtze Valley Water Environm Monitoring Ctr, 13 Yongqing Branch Rd, Wuhan 430010, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Shao,Duan, Ming,Guan, Kaiyu,et al. Developmental neurotoxicity of reserpine exposure in zebrafish larvae (Danio rerio)[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,2019,223(1):115-123. |
APA | Wang, Shao.,Duan, Ming.,Guan, Kaiyu.,Zhou, Xianyong.,Zheng, Miaomiao.,...&Li, Xi.(2019).Developmental neurotoxicity of reserpine exposure in zebrafish larvae (Danio rerio).COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,223(1),115-123. |
MLA | Wang, Shao,et al."Developmental neurotoxicity of reserpine exposure in zebrafish larvae (Danio rerio)".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 223.1(2019):115-123. |
入库方式: OAI收割
来源:水生生物研究所
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