Comparative Developmental Toxicity and Stress Protein Responses of Dimethyl Sulfoxide to Rare Minnow and Zebrafish Embryos/Larvae
文献类型：期刊论文
| 作者 | Xiong, Xiaoqin1,2; Luo, Si1,2; Wu, Benli3; Wang, Jianwei1 |
| 刊名 | ZEBRAFISH
 |
| 出版日期 | 2017-02-01 |
| 卷号 | 14期号:1页码:60-68 |
| 关键词 | dimethyl sulfoxide developmental toxicity stress protein responses rare minnow zebrafish |
| ISSN号 | 1545-8547 |
| DOI | 10.1089/zeb.2016.1287 |
| 通讯作者 | Wang, Jianwei(wangjw@ihb.ac.cn) |
| 英文摘要 | Dimethyl sulfoxide ( DMSO), a widely used carrier solvent, can be toxic to test organisms and has species-specific sensitivity. In this study, the developmental toxicity and stress protein responses of DMSO to rare minnow (Gobiocypris rarus) and zebrafish ( Danio rerio) with two tests were compared in the early life stage. In the first test, fertilized eggs were exposed to 0%, 0.0001%, 0.001%, 0.01%, 0.1%, 1.0%, 1.5%, and 2.0% v/v of DMSO until 3 days post hatching. In the second test, larvae from 0 to 8 d were exposed to 2% DMSO until 4 days. Our results showed that DMSO was toxic to rare minnow and zebrafish on multiple indexes, and the no-observed-effect concentrations of DMSO in both species were 1.0% and 0.001% for developmental toxicity analysis and stress protein analysis, respectively. Furthermore, rare minnow larvae were more sensitive than zebrafish to DMSO for spinal malformation. The sensitive period for induction of spinal malformation by DMSO was 0-7 d after hatch (dah) for rare minnow and 0-4 dah for zebrafish. Together, these results will provide support to the use of DMSO in ecotoxicological studies using rare minnow and will contribute to a better understanding of the toxicity of DMSO. |
| WOS关键词 | DANIO-RERIO EMBRYOS ; GOBIOCYPRIS-RARUS ; LARVAL DEVELOPMENT ; CARRIER SOLVENTS ; OXIDATIVE STRESS ; FATHEAD MINNOW ; DMSO ; ASSAY ; NEUROTOXICITY ; EXPOSURE |
| 资助项目 | National High-Tech Research and Development Projects[2012AA06A302-4] |
| WOS研究方向 | Developmental Biology ; Zoology |
| 语种 | 英语 |
| WOS记录号 | WOS:000392882200008 |
| 出版者 | MARY ANN LIEBERT, INC |
| 资助机构 | National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/33085]  |
| 专题 | 水生生物研究所_水生生物多样性与资源保护研究中心_期刊论文 |
| 通讯作者 | Wang, Jianwei |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, 7 Donghu South Rd, Wuhan 430072, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Anhui Acad Agr Sci, Fisheries Res Inst, Hefei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiong, Xiaoqin,Luo, Si,Wu, Benli,et al. Comparative Developmental Toxicity and Stress Protein Responses of Dimethyl Sulfoxide to Rare Minnow and Zebrafish Embryos/Larvae[J]. ZEBRAFISH,2017,14(1):60-68. |
| APA | Xiong, Xiaoqin,Luo, Si,Wu, Benli,&Wang, Jianwei.(2017).Comparative Developmental Toxicity and Stress Protein Responses of Dimethyl Sulfoxide to Rare Minnow and Zebrafish Embryos/Larvae.ZEBRAFISH,14(1),60-68. |
| MLA | Xiong, Xiaoqin,et al."Comparative Developmental Toxicity and Stress Protein Responses of Dimethyl Sulfoxide to Rare Minnow and Zebrafish Embryos/Larvae".ZEBRAFISH 14.1(2017):60-68. |
入库方式： OAI收割
来源：水生生物研究所
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