中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Comparative Developmental Toxicity and Stress Protein Responses of Dimethyl Sulfoxide to Rare Minnow and Zebrafish Embryos/Larvae

文献类型:期刊论文

作者Xiong, Xiaoqin1,2; Luo, Si1,2; Wu, Benli3; Wang, Jianwei1
刊名ZEBRAFISH
出版日期2017-02-01
卷号14期号:1页码:60-68
关键词dimethyl sulfoxide developmental toxicity stress protein responses rare minnow zebrafish
ISSN号1545-8547
DOI10.1089/zeb.2016.1287
通讯作者Wang, Jianwei(wangjw@ihb.ac.cn)
英文摘要Dimethyl sulfoxide ( DMSO), a widely used carrier solvent, can be toxic to test organisms and has species-specific sensitivity. In this study, the developmental toxicity and stress protein responses of DMSO to rare minnow (Gobiocypris rarus) and zebrafish ( Danio rerio) with two tests were compared in the early life stage. In the first test, fertilized eggs were exposed to 0%, 0.0001%, 0.001%, 0.01%, 0.1%, 1.0%, 1.5%, and 2.0% v/v of DMSO until 3 days post hatching. In the second test, larvae from 0 to 8 d were exposed to 2% DMSO until 4 days. Our results showed that DMSO was toxic to rare minnow and zebrafish on multiple indexes, and the no-observed-effect concentrations of DMSO in both species were 1.0% and 0.001% for developmental toxicity analysis and stress protein analysis, respectively. Furthermore, rare minnow larvae were more sensitive than zebrafish to DMSO for spinal malformation. The sensitive period for induction of spinal malformation by DMSO was 0-7 d after hatch (dah) for rare minnow and 0-4 dah for zebrafish. Together, these results will provide support to the use of DMSO in ecotoxicological studies using rare minnow and will contribute to a better understanding of the toxicity of DMSO.
WOS关键词DANIO-RERIO EMBRYOS ; GOBIOCYPRIS-RARUS ; LARVAL DEVELOPMENT ; CARRIER SOLVENTS ; OXIDATIVE STRESS ; FATHEAD MINNOW ; DMSO ; ASSAY ; NEUROTOXICITY ; EXPOSURE
资助项目National High-Tech Research and Development Projects[2012AA06A302-4]
WOS研究方向Developmental Biology ; Zoology
语种英语
WOS记录号WOS:000392882200008
出版者MARY ANN LIEBERT, INC
资助机构National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects ; National High-Tech Research and Development Projects
源URL[http://ir.ihb.ac.cn/handle/342005/33085]  
专题水生生物研究所_水生生物多样性与资源保护研究中心_期刊论文
通讯作者Wang, Jianwei
作者单位1.Chinese Acad Sci, Inst Hydrobiol, 7 Donghu South Rd, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Anhui Acad Agr Sci, Fisheries Res Inst, Hefei, Peoples R China
推荐引用方式
GB/T 7714
Xiong, Xiaoqin,Luo, Si,Wu, Benli,et al. Comparative Developmental Toxicity and Stress Protein Responses of Dimethyl Sulfoxide to Rare Minnow and Zebrafish Embryos/Larvae[J]. ZEBRAFISH,2017,14(1):60-68.
APA Xiong, Xiaoqin,Luo, Si,Wu, Benli,&Wang, Jianwei.(2017).Comparative Developmental Toxicity and Stress Protein Responses of Dimethyl Sulfoxide to Rare Minnow and Zebrafish Embryos/Larvae.ZEBRAFISH,14(1),60-68.
MLA Xiong, Xiaoqin,et al."Comparative Developmental Toxicity and Stress Protein Responses of Dimethyl Sulfoxide to Rare Minnow and Zebrafish Embryos/Larvae".ZEBRAFISH 14.1(2017):60-68.

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来源:水生生物研究所

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