The P Protein of Spring Viremia of Carp Virus Negatively Regulates the Fish Interferon Response by Inhibiting the Kinase Activity of TANK-Binding Kinase 1
文献类型:期刊论文
作者 | Li, Shun1; Lu, Long-Feng1,2; Wang, Zhao-Xi1,2; Lu, Xiao-Bing1,2; Chen, Dan-Dan1; Nie, Pin1; Zhang, Yong-An1 |
刊名 | JOURNAL OF VIROLOGY |
出版日期 | 2016-12-01 |
卷号 | 90期号:23页码:10728-10737 |
ISSN号 | 0022-538X |
DOI | 10.1128/JVI.01381-16 |
英文摘要 | Spring viremia of carp virus (SVCV) is an efficient pathogen causing high mortality in the common carp. Fish interferon (IFN) is a powerful cytokine enabling host cells to establish an antiviral response; therefore, the strategies that SVCV uses to avoid the cellular IFN response were investigated. Here, we report that the SVCV P protein is phosphorylated by cellular TANK-binding kinase 1 (TBK1), which decreases IFN regulatory factor 3 (IRF3) phosphorylation and suppresses IFN production. First, overexpression of P protein inhibited the IFN promoter activation induced by SVCV and the IFN activity activated by the mitochondrial antiviral signaling protein (MAVS) although TBK1 activity was not blocked by P protein. Second, P protein colocalized and interacted with TBK1. Dominant negative experiments suggested that the TBK1 N-terminal kinase domain interacted with P protein and was essential for P protein and IRF3 phosphorylation. Finally, P protein overexpression reduced the IRF3 phosphorylation activated by TBK1 and reduced host cellular ifn transcription. Collectively, our data demonstrated that the SVCV P protein is a decoy substrate for the host phosphokinase TBK1, preventing IFN production and facilitating SVCV replication. IMPORTANCE TBK1 is a pivotal phosphokinase that activates host IFN production to defend against viral infection; thus, it is a potential target for viruses to negatively regulate IFN response and facilitate viral evasion. We report that the SVCV P protein functions as a decoy substrate for cellular TBK1, leading to the reduction of IRF3 phosphorylation and suppression of IFN expression. These findings reveal a novel immune evasion mechanism of SVCV. |
WOS关键词 | ANTIVIRAL SIGNALING PROTEIN ; VESICULAR STOMATITIS-VIRUS ; INNATE IMMUNE-RESPONSE ; I-LIKE RECEPTORS ; NF-KAPPA-B ; RIG-I ; TRANSCRIPTIONAL ACTIVITY ; VIRAL-INFECTION ; IFN RESPONSES ; IRF3 |
资助项目 | National Basic Research Program of China[2014CB138601] ; National Natural Science Foundation of China (NSFC)[31502200] ; Chinese Academy of Sciences (CAS)[Y65E01-1-501] |
WOS研究方向 | Virology |
语种 | 英语 |
出版者 | AMER SOC MICROBIOLOGY |
WOS记录号 | WOS:000389904500024 |
资助机构 | National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; 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Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; Chinese Academy of Sciences (CAS) ; Chinese Academy of Sciences (CAS) ; 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源URL | [http://ir.ihb.ac.cn/handle/342005/31894] |
专题 | 水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文 |
通讯作者 | Zhang, Yong-An |
作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Shun,Lu, Long-Feng,Wang, Zhao-Xi,et al. The P Protein of Spring Viremia of Carp Virus Negatively Regulates the Fish Interferon Response by Inhibiting the Kinase Activity of TANK-Binding Kinase 1[J]. JOURNAL OF VIROLOGY,2016,90(23):10728-10737. |
APA | Li, Shun.,Lu, Long-Feng.,Wang, Zhao-Xi.,Lu, Xiao-Bing.,Chen, Dan-Dan.,...&Zhang, Yong-An.(2016).The P Protein of Spring Viremia of Carp Virus Negatively Regulates the Fish Interferon Response by Inhibiting the Kinase Activity of TANK-Binding Kinase 1.JOURNAL OF VIROLOGY,90(23),10728-10737. |
MLA | Li, Shun,et al."The P Protein of Spring Viremia of Carp Virus Negatively Regulates the Fish Interferon Response by Inhibiting the Kinase Activity of TANK-Binding Kinase 1".JOURNAL OF VIROLOGY 90.23(2016):10728-10737. |
入库方式: OAI收割
来源:水生生物研究所
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