Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome
文献类型:期刊论文
作者 | Hamilton, Eileen P.1; Kapusta, Aurelie2; Huvos, Piroska E.3; Bidwell, Shelby L.4; Zafar, Nikhat4; Tang, Haibao4; Hadjithomas, Michalis4; Krishnakumar, Vivek4; Badger, Jonathan H.4; Caler, Elisabet V.4 |
刊名 | ELIFE |
出版日期 | 2016-11-28 |
卷号 | 5期号:1页码:46 |
ISSN号 | 2050-084X |
DOI | 10.7554/eLife.19090 |
英文摘要 | The germline genome of the binucleated ciliate Tetrahymena thermophila undergoes programmed chromosome breakage and massive DNA elimination to generate the somatic genome. Here, we present a complete sequence assembly of the germline genome and analyze multiple features of its structure and its relationship to the somatic genome, shedding light on the mechanisms of genome rearrangement as well as the evolutionary history of this remarkable germline/soma differentiation. Our results strengthen the notion that a complex, dynamic, and ongoing interplay between mobile DNA elements and the host genome have shaped Tetrahymena chromosome structure, locally and globally. Non-standard outcomes of rearrangement events, including the generation of short-lived somatic chromosomes and excision of DNA interrupting protein-coding regions, may represent novel forms of developmental gene regulation. We also compare Tetrahymenas germline/soma differentiation to that of other characterized ciliates, illustrating the wide diversity of adaptations that have occurred within this phylum. |
WOS关键词 | CHROMOSOME BREAKAGE SITES ; PROGRAMMED DNA ELIMINATION ; CIS-ACTING SEQUENCES ; RIBOSOMAL-RNA GENE ; PARAMECIUM-TETRAURELIA ; TRANSPOSABLE ELEMENTS ; WIDE CHARACTERIZATION ; CHROMATIN DIMINUTION ; V(D)J RECOMBINATION ; NUCLEOTIDE-SEQUENCE |
资助项目 | National Institutes of Health[GM077582] ; Natural Science Foundation of Hubei Province[31525021] ; National Science Foundation[MCB-1158346] |
WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
语种 | 英语 |
出版者 | ELIFE SCIENCES PUBLICATIONS LTD |
WOS记录号 | WOS:000391710700001 |
资助机构 | National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation |
源URL | [http://ir.ihb.ac.cn/handle/342005/33128] |
专题 | 水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文 |
通讯作者 | Coyne, Robert S. |
作者单位 | 1.Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA 2.Univ Utah, Sch Med, Dept Human Genet, Salt Lake City, UT 84132 USA 3.Southern Illinois Univ, Biochem & Mol Biol, Carbondale, IL USA 4.J Craig Venter Inst, Rockville, MD USA 5.Eli & Edythe L Broad Inst Harvard & MIT, Cambridge, MA USA 6.Inst Mol Biotechnol, Vienna, Austria 7.Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA 8.MRC Lab Mol Biol, Cambridge, England 9.Cornell Univ, Dept Microbiol & Immunol, Ithaca, NY USA 10.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China |
推荐引用方式 GB/T 7714 | Hamilton, Eileen P.,Kapusta, Aurelie,Huvos, Piroska E.,et al. Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome[J]. ELIFE,2016,5(1):46. |
APA | Hamilton, Eileen P..,Kapusta, Aurelie.,Huvos, Piroska E..,Bidwell, Shelby L..,Zafar, Nikhat.,...&Coyne, Robert S..(2016).Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome.ELIFE,5(1),46. |
MLA | Hamilton, Eileen P.,et al."Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome".ELIFE 5.1(2016):46. |
入库方式: OAI收割
来源:水生生物研究所
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