D-Proline capped gold nanoclusters for turn-on detection of serum Raltitrexed
文献类型：期刊论文
| 作者 | Lan, Weifei; Tan, Qiqi; Qiao, Juan; Shen, Gangyi; Qi, Li |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2019-09-01 |
| 卷号 | 30期号:9页码:1627-1630 |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2019.05.019 |
| 英文摘要 | With D-proline as the reducing and capping agent, fluorescent gold nanoclusters were rapidly prepared (D-Pro@AuNCs) within 10 min at 100 degrees C. In the present of gold nanoparticles, the fluorescence of D-Pro@AuNCs was remarkably quenched. Interestingly, based on the electrostatic interaction between anticancer drug Raltitrexed and gold nanoparticles induced fluorescence "turn-on" principle, a high selective assay for detection of Raltitrexed was established with the probe associating the fluorescence emission at 435 nm. The fluorescence intensity of D-Pro@AuNCs linearly correlated with the concentration of Raltitrexed in the range from 5.0 mu mol/L to 40.0 mu mol/L (R-2 = 0.999) and the limit of detection was 1.9 mu mol/L. Further, after Raltitrexed was abdominal injected in rats, a metabolic approach was constructed with the prepared fluorescent probe. It showed great potential of AuNCs-based sensing probes for application in analysis of serum anticancer drugs. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000482530200011 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/82617]  |
| 专题 | 中国科学院化学研究所 |
| 作者单位 | Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lan, Weifei,Tan, Qiqi,Qiao, Juan,et al. D-Proline capped gold nanoclusters for turn-on detection of serum Raltitrexed[J]. CHINESE CHEMICAL LETTERS,2019,30(9):1627-1630. |
| APA | Lan, Weifei,Tan, Qiqi,Qiao, Juan,Shen, Gangyi,&Qi, Li.(2019).D-Proline capped gold nanoclusters for turn-on detection of serum Raltitrexed.CHINESE CHEMICAL LETTERS,30(9),1627-1630. |
| MLA | Lan, Weifei,et al."D-Proline capped gold nanoclusters for turn-on detection of serum Raltitrexed".CHINESE CHEMICAL LETTERS 30.9(2019):1627-1630. |
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来源：化学研究所
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