A Nanobody-Conjugated DNA Nanoplatform for Targeted Platinum-Drug Delivery
文献类型：期刊论文
| 作者 | Wu, Tiantian; Liu, Jianbing; Liu, Manman; Liu, Shaoli; Zhao, Shuai; Tian, Run; Wei, Dengshuai; Liu, Yangzhong; Zhao, Yao; Xiao, Haihua |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2019-09-01 |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201909345 |
| 英文摘要 | The targeted delivery of chemotherapeutic drugs is a major challenge in the clinical treatment of cancer. Herein, we constructed a multifunctional DNA nanoplatform as a versatile carrier of the highly potent platinum-based DNA intercalator, 56MESS. In our rational design, 56MESS was efficiently loaded into the double-bundle DNA tetrahedron through intercalation with the DNA duplex. With the integration of a nanobody that both targets and blocks epidermal growth factor receptor (EGFR), the DNA nanocarriers exhibit excellent selectivity for cells with elevated EGFR expression (a common biomarker related to tumor formation) and combined tumor therapy without obvious systemic toxicity. This DNA-based platinum-drug delivery system provides a promising strategy for the treatment of tumors. |
| 语种 | 英语 |
| WOS记录号 | WOS:000483626000001 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/82635]  |
| 专题 | 中国科学院化学研究所 |
| 作者单位 | Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Tiantian,Liu, Jianbing,Liu, Manman,et al. A Nanobody-Conjugated DNA Nanoplatform for Targeted Platinum-Drug Delivery[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019. |
| APA | Wu, Tiantian.,Liu, Jianbing.,Liu, Manman.,Liu, Shaoli.,Zhao, Shuai.,...&Ding, Baoquan.(2019).A Nanobody-Conjugated DNA Nanoplatform for Targeted Platinum-Drug Delivery.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. |
| MLA | Wu, Tiantian,et al."A Nanobody-Conjugated DNA Nanoplatform for Targeted Platinum-Drug Delivery".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019). |
入库方式： OAI收割
来源：化学研究所
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