Coordinatively Unsaturated Fe3+ Based Activatable Probes for Enhanced MRI and Therapy of Tumors
文献类型：期刊论文
| 作者 | Zhang, Peisen; Hou, Yi; Zeng, Jianfeng; Li, Yingying; Wang, Zihua; Zhu, Ran; Ma, Tiancong; Gao, Mingyuan |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2019-08-05 |
| 卷号 | 58期号:32页码:11088-11096 |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201904880 |
| 英文摘要 | Exogenous Fe-III can be used for cancer magnetic resonance (MR) imaging and potentially for cancer treatment by a ferroptosis pathway or photothermal ablation. To achieve this, effective and accurate delivery of Fe-III to cancerous sites is critical, requiring a balance of release kinetics of Fe3+ in tumorous and normal tissues. A nanoprobe is described consisting of upconversion luminescence (UCL) nanoparticles as a core and a coordinatively unsaturated Fe-III-containing Fe3+/gallic acid complex as a shell. Owing to the introduction of an unsaturated coordination structure, Fe-III in the nanoprobe can be released only in the tumor microenvironment in response to the lightly acidic pH. The multiple UCLs are used for quantitatively visualizing the release of Fe3+ in vivo, whilst the release resultant serves as a photothermal agent. This nanoprobe exhibited ligand-free tumor targeting ability, activatable MR imaging performance, and efficacious therapeutic effects against tumors in vivo. |
| 语种 | 英语 |
| WOS记录号 | WOS:000478635100055 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/82682]  |
| 专题 | 中国科学院化学研究所 |
| 作者单位 | Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Peisen,Hou, Yi,Zeng, Jianfeng,et al. Coordinatively Unsaturated Fe3+ Based Activatable Probes for Enhanced MRI and Therapy of Tumors[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(32):11088-11096. |
| APA | Zhang, Peisen.,Hou, Yi.,Zeng, Jianfeng.,Li, Yingying.,Wang, Zihua.,...&Gao, Mingyuan.(2019).Coordinatively Unsaturated Fe3+ Based Activatable Probes for Enhanced MRI and Therapy of Tumors.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(32),11088-11096. |
| MLA | Zhang, Peisen,et al."Coordinatively Unsaturated Fe3+ Based Activatable Probes for Enhanced MRI and Therapy of Tumors".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.32(2019):11088-11096. |
入库方式： OAI收割
来源：化学研究所
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