Gold nanorods based multicompartment mesoporous silica composites as bioagents for highly efficient photothermal therapy
文献类型：期刊论文
| 作者 | Zhao, Jie; Wang, Anhe; Si, Tieyan; Hong, Jong-Dal; Li, Junbai |
| 刊名 | JOURNAL OF COLLOID AND INTERFACE SCIENCE
 |
| 出版日期 | 2019-08-01 |
| 卷号 | 549页码:9-15 |
| ISSN号 | 0021-9797 |
| DOI | 10.1016/j.jcis.2019.04.051 |
| 英文摘要 | Photothermal therapy (PTT) based on photothermal effect of the gold nanostructures, has been widely applied as a noninvasive therapy approach in cancer treatment. However, bare Au nanoparticles are not stable enough during the irradiation process, and cannot harvest sufficient energy to kill tumor cells. To improve this, we have fabricated a stable bioagent by loading gold nanorods (AuNRs) into multicompartment mesoporous silica nanoparticles (MMSNs) for the photothermal therapy. The procedure is that when AuNRs entrapped in MMSNs are irradiated by a laser in the near-infrared region of 808 nm, the hyperthermia produced by the assembled composites is strong enough to damage tumor tissues directly. Both experiments in vitro and in vivo demonstrate that the nanocomposites are perfect candidates as PTT agents for the cancer treatment with a high efficiency. Furthermore, it is found that the nanocomposites have good photostability and consistent temperature fluctuation over 11 on/off cycles with irradiation which the pure AuNRs will not have. (C) 2019 Elsevier Inc. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000469902100002 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/82715]  |
| 专题 | 中国科学院化学研究所 |
| 作者单位 | Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Jie,Wang, Anhe,Si, Tieyan,et al. Gold nanorods based multicompartment mesoporous silica composites as bioagents for highly efficient photothermal therapy[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2019,549:9-15. |
| APA | Zhao, Jie,Wang, Anhe,Si, Tieyan,Hong, Jong-Dal,&Li, Junbai.(2019).Gold nanorods based multicompartment mesoporous silica composites as bioagents for highly efficient photothermal therapy.JOURNAL OF COLLOID AND INTERFACE SCIENCE,549,9-15. |
| MLA | Zhao, Jie,et al."Gold nanorods based multicompartment mesoporous silica composites as bioagents for highly efficient photothermal therapy".JOURNAL OF COLLOID AND INTERFACE SCIENCE 549(2019):9-15. |
入库方式： OAI收割
来源：化学研究所
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