Luminescent, Oxygen-Supplying, Hemoglobin-Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy
文献类型：期刊论文
| 作者 | Jiang, Linye; Bai, Haotian; Liu, Libing; Lv, Fengting; Ren, Xueqin; Wang, Shu |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2019-07-29 |
| 卷号 | 58期号:31页码:10660-10665 |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201905884 |
| 英文摘要 | Photodynamic therapy (PDT) is a promising method for cancer treatment. Two parameters that influence the efficacy of PDT are the light source and oxygen supply. Herein, we prepared a system for PDT using hemoglobin (Hb)-linked conjugated polymer nanoparticles (CPNs), which can luminesce and supply oxygen. Hb catalyzes the activation of luminol, the conjugated polymer poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene] (MEH-PPV) nanoparticles can absorb the chemiluminescence of luminol through chemiluminescence resonance energy transfer (CRET) and then sensitize the oxygen supplied by Hb to produce reactive oxygen species that kill cancer cells. This system could be used for the controlled release of an anticancer prodrug. The system does not need an external light source and circumvents the insufficient level molecular oxygen under hypoxia. This work provides a proof-of-concept to explore smart and multifunctional nanoplatforms for phototherapy. |
| 语种 | 英语 |
| WOS记录号 | WOS:000476919100043 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/82719]  |
| 专题 | 中国科学院化学研究所 |
| 作者单位 | Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Linye,Bai, Haotian,Liu, Libing,et al. Luminescent, Oxygen-Supplying, Hemoglobin-Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(31):10660-10665. |
| APA | Jiang, Linye,Bai, Haotian,Liu, Libing,Lv, Fengting,Ren, Xueqin,&Wang, Shu.(2019).Luminescent, Oxygen-Supplying, Hemoglobin-Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(31),10660-10665. |
| MLA | Jiang, Linye,et al."Luminescent, Oxygen-Supplying, Hemoglobin-Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.31(2019):10660-10665. |
入库方式： OAI收割
来源：化学研究所
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