An Injectable Strong Hydrogel for Bone Reconstruction
文献类型：期刊论文
| 作者 | Zhao, Yanran; Cui, Zhiyong; Liu, Bingchuan; Xiang, Junfeng; Qiu, Dong; Tian, Yun; Qu, Xiaozhong; Yang, Zhenzhong |
| 刊名 | ADVANCED HEALTHCARE MATERIALS
 |
| 出版日期 | 2019-07-26 |
| ISSN号 | 2192-2640 |
| DOI | 10.1002/adhm.201900709 |
| 英文摘要 | For treating bone defects in periarticular fractures, there is a lack of biomaterial with injectable characteristics, tough structure, and osteogenic capacity for providing a whole-structure support and osteogenesis in the defect area. An injectable hydrogel is an ideal implant, however is weak as load-bearing scaffolds. Herein, a new strategy, i.e., an in situ formation of "active" composite double network (DN), is raised for the preparation of an injectable strong hydrogel particularly against compression. As a demonstration, 4-carboxyphenylboronic acid grafted poly(vinyl alcohol) (PVA) is crosslinked using calcium ions to provide a tough frame while bioactive glass (BG) microspheres are associated by poly(ethylene glycol) to obtain an interpenetrated inorganic network for reinforcement. The injected PVA/BG DN hydrogel gains compressive strength, modulus, and fracture energy of 34 MPa, 0.8 MPa, and 40 kJ m(-2), respectively. Then, the properties can be "autostrengthened" to 57 MPa, 2 MPa, and 65 kJ m(-2) by mineralization in 14 days. In vivo experiments prove that the injected DN hydrogel is more efficient to treat femoral supracondylar bone defects than the implanted bulk DN gel. The work suggests a facile way to obtain a strong hydrogel with injectability, cytocompatibility, and tailorable functionality. |
| 语种 | 英语 |
| WOS记录号 | WOS:000478497200001 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/82721]  |
| 专题 | 中国科学院化学研究所 |
| 作者单位 | Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Yanran,Cui, Zhiyong,Liu, Bingchuan,et al. An Injectable Strong Hydrogel for Bone Reconstruction[J]. ADVANCED HEALTHCARE MATERIALS,2019. |
| APA | Zhao, Yanran.,Cui, Zhiyong.,Liu, Bingchuan.,Xiang, Junfeng.,Qiu, Dong.,...&Yang, Zhenzhong.(2019).An Injectable Strong Hydrogel for Bone Reconstruction.ADVANCED HEALTHCARE MATERIALS. |
| MLA | Zhao, Yanran,et al."An Injectable Strong Hydrogel for Bone Reconstruction".ADVANCED HEALTHCARE MATERIALS (2019). |
入库方式： OAI收割
来源：化学研究所
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