IgE induces hypotension in asthma mice by down-regulating vascular NCX1 expression through activating MiR-212-5p
文献类型：期刊论文
| 作者 | Liu, B; Zhang, W ; Gao, R; Li, Y; Cui, XX; Ren, M; Yan, L; Song, XM; Zhao, HM; Hu Y(胡毅)
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| 刊名 | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
 |
| 出版日期 | 2018 |
| 卷号 | 1864期号:1页码:189-196 |
| 关键词 | Asthma IgE Fc epsilon R1(-/-) Hypotension |
| ISSN号 | 0925-4439 |
| DOI | 10.1016/j.bbadis.2017.10.011 |
| 文献子类 | Article |
| 英文摘要 | Immunoglobulin E (IgE) has been suggested as a risk factor for allergy-induced low blood pressure, which has not been well explained in molecular details. Our current study shows a novel mechanism involving IgE, Fc epsilon R1, miRNA-212-5p (miR-212-5p), and sodium/calcium exchanger protein 1(NCX1) for asthma to induce hypotension. In arterial smooth muscle cells, IgE up-regulated miR212-5p via its receptor FceR1, which resulted in down regulation of NCX1 that is a regulating factor for blood pressure. In mice, asthma induced hypotension by interfering vasoconstrictive function; knockout of FceR1 kept the asthmatic mice from developing hypotension; knock-down of miR-212-5p in asthmatic mice resulted in a significant restoration of blood pressure. In human, asthma and IgE were positively correlated with hypotension in cohort study on NIH epidemiological data. This study suggests a novel therapeutic target (miR-212-5p) for treatment of asthma-induced hypotension. |
| 电子版国际标准刊号 | 0006-3002 |
| WOS关键词 | SMOOTH-MUSCLE-CELLS ; ANAPHYLACTIC HYPOTENSION ; DIASTOLIC HYPOTENSION ; SUDDEN-DEATH ; HYPERTENSION ; CHILDREN ; RATS ; MANAGEMENT ; RISK |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000418219900018 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285505]  |
| 专题 | 中国科学院高能物理研究所_文献信息部 高能物理研究所_实验物理中心 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Liu, B,Zhang, W,Gao, R,et al. IgE induces hypotension in asthma mice by down-regulating vascular NCX1 expression through activating MiR-212-5p[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,2018,1864(1):189-196. |
| APA | Liu, B.,Zhang, W.,Gao, R.,Li, Y.,Cui, XX.,...&Liu, MB.(2018).IgE induces hypotension in asthma mice by down-regulating vascular NCX1 expression through activating MiR-212-5p.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,1864(1),189-196. |
| MLA | Liu, B,et al."IgE induces hypotension in asthma mice by down-regulating vascular NCX1 expression through activating MiR-212-5p".BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1864.1(2018):189-196. |
入库方式： OAI收割
来源：高能物理研究所
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