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Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria
文献类型：期刊论文
| 作者 | Perez-Aguilar, JM; Li, WF; Fang, G; Chen CY(陈春英); Zhou, RH; Ge, CC; Chen, CY; Chai, ZF ; Gao, XF; Shen, XM
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| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2018 |
| 卷号 | 9页码:129 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-017-02502-3 |
| 文献子类 | Article |
| 英文摘要 | Noble metal-based nanomaterials have shown promise as potential enzyme mimetics, but the facet effect and underlying molecular mechanisms are largely unknown. Herein, with a combined experimental and theoretical approach, we unveil that palladium (Pd) nanocrystals exhibit facet-dependent oxidase and peroxidase-like activities that endow them with excellent antibacterial properties via generation of reactive oxygen species. The antibacterial efficiency of Pd nanocrystals against Gram-positive bacteria is consistent with the extent of their enzyme-like activity, that is {100}-faceted Pd cubes with higher activities kill bacteria more effectively than {111}-faceted Pd octahedrons. Surprisingly, a reverse trend of antibacterial activity is observed against Gram-negative bacteria, with Pd octahedrons displaying stronger penetration into bacterial membranes than Pd nanocubes, thereby exerting higher antibacterial activity than the latter. Our findings provide a deeper understanding of facet-dependent enzyme-like activities and might advance the development of noble metal-based nanomaterials with both enhanced and targeted antibacterial activities. |
| WOS关键词 | ANTIMICROBIAL AGENTS ; GOLD NANOPARTICLES ; ESCHERICHIA-COLI ; PALLADIUM NANOCRYSTALS ; SILVER NANOPARTICLES ; CATALYTIC-ACTIVITIES ; RESISTANT BACTERIA ; CARBON NANOTUBES ; ASCORBIC-ACID ; MECHANISM |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000419658100028 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285527]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Perez-Aguilar, JM,Li, WF,Fang, G,et al. Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria[J]. NATURE COMMUNICATIONS,2018,9:129. |
| APA | Perez-Aguilar, JM.,Li, WF.,Fang, G.,陈春英.,Zhou, RH.,...&Chong, Y.(2018).Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria.NATURE COMMUNICATIONS,9,129. |
| MLA | Perez-Aguilar, JM,et al."Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria".NATURE COMMUNICATIONS 9(2018):129. |
入库方式： OAI收割
来源：高能物理研究所
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