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The antihyperlipidemic effects of fullerenol nanoparticles via adjusting the gut microbiota in vivo

文献类型：期刊论文

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作者Li J(李娟); Lei RH(雷润宏); Xiong FX(熊凤霞); Yang SM(杨生梅); Chang YN(常亚男); Chen K(陈奎); Gu WH(古伟宏); Xing GM(邢更妹); Li, J; Lei, RH
刊名PARTICLE AND FIBRE TOXICOLOGY ; PARTICLE AND FIBRE TOXICOLOGY
出版日期2018 ; 2018
卷号15页码:5
关键词Fullerenols Fullerenols Gut microbiota Short-chain fatty acid (SCFA) Blood lipids Butyrate-producing bacteria Gut microbiota Short-chain fatty acid (SCFA) Blood lipids Butyrate-producing bacteria
ISSN号1743-8977 ; 1743-8977
DOI10.1186/s12989-018-0241-9 ; 10.1186/s12989-018-0241-9
文献子类Article ; Article
英文摘要Background: Nanoparticles (NPs) administered orally will meet the gut microbiota, but their impacts on microbiota homeostasis and the consequent physiological relevance remain largely unknown. Here, we describe the modulatory effects and the consequent pharmacological outputs of two orally administered fullerenols NPs (Fol1 C-60(OH)(7)(O)(8) and Fol113 C-60(OH)(11)(O)(6)) on gut microbiota. Results: Administration of Fol1 and Fol113 NPs for 4 weeks largely shifted the overall structure of gut microbiota in mice. The bacteria belonging to putative short-chain fatty acids (SCFAs)-producing genera were markedly increased by both NPs, especially Fol1. Dynamic analysis showed that major SCFAs-producers and key butyrate-producing gene were significantly enriched after treatment for 7-28 days. The fecal contents of SCFAs were consequently increased, which was accompanied by significant decreases of triglycerides and total cholesterol levels in the blood and liver, with Fol1 superior to Fol113. Under cultivation in vitro, fullerenols NPs can be degraded by gut flora and exhibited a similar capacity of inulin to promote SCFA-producing genera. The differential effects of Fol1 and Fol113 NPs on the microbiome may be attributable to their subtly varied surface structures. Conclusions: The two fullerenol NPs remarkably modulate the gut microbiota and selectively enrich SCFA-producing bacteria, which may be an important reason for their anti-hyperlipidemic effect in mice.; Background: Nanoparticles (NPs) administered orally will meet the gut microbiota, but their impacts on microbiota homeostasis and the consequent physiological relevance remain largely unknown. Here, we describe the modulatory effects and the consequent pharmacological outputs of two orally administered fullerenols NPs (Fol1 C-60(OH)(7)(O)(8) and Fol113 C-60(OH)(11)(O)(6)) on gut microbiota. Results: Administration of Fol1 and Fol113 NPs for 4 weeks largely shifted the overall structure of gut microbiota in mice. The bacteria belonging to putative short-chain fatty acids (SCFAs)-producing genera were markedly increased by both NPs, especially Fol1. Dynamic analysis showed that major SCFAs-producers and key butyrate-producing gene were significantly enriched after treatment for 7-28 days. The fecal contents of SCFAs were consequently increased, which was accompanied by significant decreases of triglycerides and total cholesterol levels in the blood and liver, with Fol1 superior to Fol113. Under cultivation in vitro, fullerenols NPs can be degraded by gut flora and exhibited a similar capacity of inulin to promote SCFA-producing genera. The differential effects of Fol1 and Fol113 NPs on the microbiome may be attributable to their subtly varied surface structures. Conclusions: The two fullerenol NPs remarkably modulate the gut microbiota and selectively enrich SCFA-producing bacteria, which may be an important reason for their anti-hyperlipidemic effect in mice.
WOS关键词CHAIN FATTY-ACIDS ; CHAIN FATTY-ACIDS ; CARBON NANOTUBES ; METABOLITES ; BACTERIA ; INSIGHTS ; THERAPY ; HEALTH ; MICE ; C-60 ; CARBON NANOTUBES ; METABOLITES ; BACTERIA ; INSIGHTS ; THERAPY ; HEALTH ; MICE ; C-60
WOS研究方向Toxicology ; Toxicology
语种英语 ; 英语
WOS记录号WOS:000422875000001 ; WOS:000422875000001
源URL[http://ir.ihep.ac.cn/handle/311005/285544]  
专题高能物理研究所_多学科研究中心
通讯作者Xing GM(邢更妹)
作者单位中国科学院高能物理研究所
推荐引用方式
GB/T 7714		 Li J,Lei RH,Xiong FX,et al. The antihyperlipidemic effects of fullerenol nanoparticles via adjusting the gut microbiota in vivo, The antihyperlipidemic effects of fullerenol nanoparticles via adjusting the gut microbiota in vivo[J]. PARTICLE AND FIBRE TOXICOLOGY, PARTICLE AND FIBRE TOXICOLOGY,2018, 2018,15, 15:5, 5.
APA 李娟.,雷润宏.,熊凤霞.,杨生梅.,常亚男.,...&Xing, GM.(2018).The antihyperlipidemic effects of fullerenol nanoparticles via adjusting the gut microbiota in vivo.PARTICLE AND FIBRE TOXICOLOGY,15,5.
MLA 李娟,et al."The antihyperlipidemic effects of fullerenol nanoparticles via adjusting the gut microbiota in vivo".PARTICLE AND FIBRE TOXICOLOGY 15(2018):5.

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来源：高能物理研究所

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