Biodegradable MoOx nanoparticles with efficient near-infrared photothermal and photodynamic synergetic cancer therapy at the second biological window
文献类型：期刊论文
| 作者 | Gu ZJ(谷战军) ; Dong XH(董兴华); Yu J(余杰); Gao Q(高琴); Zhang X(张潇); Bo T(薄涛); Zhao, YL; Gu, ZJ; Yan, L; Dong, XH
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| 刊名 | NANOSCALE
 |
| 出版日期 | 2018 |
| 卷号 | 10期号:3页码:1517-1531 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c7nr07927c |
| 文献子类 | Article |
| 英文摘要 | Near-infrared (NIR) laser induced phototherapy has been considered as a noninvasive option for cancer therapy. Herein, we report plasmonic PEGylated molybdenum oxide nanoparticles (PEG-MoOx NPs) that were synthesized by using a facile hydrothermal method. The PEG-MoOx NPs exhibit broad absorption at the NIR biological window and remarkable photothermal conversion ability in the first (808 nm) and the second (1064 nm) windows. Moreover, the biocompatible PEG-MoOx NPs exhibit effective cellular uptake and could be eliminated gradually from the liver and spleen in mice. Studies on the therapeutic effects of these NPs under 808 and 1064 nm exposures with mild hyperthermia are conducted. According to the result, exposure to 1064 nm irradiation can not only effectively convert light into heat but also sensitize the formation of reactive oxygen species (ROS), which exert dramatic cancer cell death and suppression in vivo due to the synergic effect of photothermal therapy (PTT) and photodynamic therapy (PDT). In marked contrast, 808 nm irradiation can only execute limited PTT to cancer cells, showing a relatively low inhibition rate in vitro and in vivo. This biodegradable MoOx nanoplatform with synergetic PTT and PDT functionalities upon 1064 nm irradiation provided emerging opportunities for the phototherapy of cancer in nanomedicine. |
| 电子版国际标准刊号 | 2040-3372 |
| WOS关键词 | SURFACE-PLASMON RESONANCES ; IN-VIVO ; GOLD NANORODS ; SEMICONDUCTOR NANOCRYSTALS ; MILD HYPERTHERMIA ; TUNGSTEN-OXIDE ; SINGLET OXYGEN ; 1064 NM ; LIGHT ; NANOMATERIALS |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000423259000069 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285571]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_实验物理中心 |
| 通讯作者 | Gu ZJ(谷战军) |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Gu ZJ,Dong XH,Yu J,et al. Biodegradable MoOx nanoparticles with efficient near-infrared photothermal and photodynamic synergetic cancer therapy at the second biological window[J]. NANOSCALE,2018,10(3):1517-1531. |
| APA | 谷战军.,董兴华.,余杰.,高琴.,张潇.,...&赵宇亮.(2018).Biodegradable MoOx nanoparticles with efficient near-infrared photothermal and photodynamic synergetic cancer therapy at the second biological window.NANOSCALE,10(3),1517-1531. |
| MLA | 谷战军,et al."Biodegradable MoOx nanoparticles with efficient near-infrared photothermal and photodynamic synergetic cancer therapy at the second biological window".NANOSCALE 10.3(2018):1517-1531. |
入库方式： OAI收割
来源：高能物理研究所
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