Selective Surface Enhanced Raman Scattering for Quantitative Detection of Lung Cancer Biomarkers in Superparticle@MOF Structure
文献类型：期刊论文
| 作者 | Liu, C; Qiao, XZ; Su, BS; Song, Q; Luo, D; Mo, G ; Wang, T; Mo G(默广)
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| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2018 |
| 卷号 | 30期号:5页码:1702275 |
| ISSN号 | 0935-9648 |
| 关键词 | biomarkers self-assembly surface enhanced Raman scattering (SERS) superparticles volatile organic compounds (VOCs) |
| DOI | 10.1002/adma.201702275 |
| 文献子类 | Article |
| 英文摘要 | Surface enhanced Raman scattering (SERS) is a trace detection technique that extends even to single molecule detection. Its potential application to the noninvasive recognition of lung malignancies by detecting volatile organic compounds (VOCs) that serve as biomarkers would be a breakthrough in early cancer diagnostics. This application, however, is currently limited by two main factors: (1) most VOC biomarkers exhibit only weak Raman scattering; and (2) the high mobility of gaseous molecules results in a low adsorptivity on solid substrates. To enhance the adsorption of gaseous molecules, a ZIF-8 layer is coated onto a self-assembly of gold superparticles (GSPs) in order to slow the flow rate of gaseous biomarkers and depress the exponential decay of the electromagnetic field around the GSP surfaces. Gaseous aldehydes that are released as a result of tumor-specific tissue composition and metabolism, thereby acting as indicators of lung cancer, are guided onto SERS-active GSPs substrates through a ZIF-8 channel. Through a Schiff base reaction with 4-aminothiophenol pregrafted onto gold GSPs, gaseous aldehydes are captured with a 10 ppb limit of detection, demonstrating tremendous prospects for in vitro diagnoses of early stage lung cancer. |
| 电子版国际标准刊号 | 1521-4095 |
| WOS关键词 | METAL-ORGANIC FRAMEWORKS ; ZEOLITIC IMIDAZOLATE FRAMEWORKS ; SINGLE-MOLECULE ; COLLOIDAL SUPERPARTICLES ; EXHALED BREATH ; SERS ; NANOPARTICLES ; NANOCRYSTALS ; SPECTROSCOPY ; CATALYSIS |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000423793100028 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285584]  |
| 专题 | 中国科学院高能物理研究所_中国散裂中子源 高能物理研究所_多学科研究中心 高能物理研究所_东莞分部 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Liu, C,Qiao, XZ,Su, BS,et al. Selective Surface Enhanced Raman Scattering for Quantitative Detection of Lung Cancer Biomarkers in Superparticle@MOF Structure[J]. ADVANCED MATERIALS,2018,30(5):1702275. |
| APA | Liu, C.,Qiao, XZ.,Su, BS.,Song, Q.,Luo, D.,...&默广.(2018).Selective Surface Enhanced Raman Scattering for Quantitative Detection of Lung Cancer Biomarkers in Superparticle@MOF Structure.ADVANCED MATERIALS,30(5),1702275. |
| MLA | Liu, C,et al."Selective Surface Enhanced Raman Scattering for Quantitative Detection of Lung Cancer Biomarkers in Superparticle@MOF Structure".ADVANCED MATERIALS 30.5(2018):1702275. |
入库方式： OAI收割
来源：高能物理研究所
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