Intelligent MoS2 Nanotheranostic for Targeted and Enzyme-/pH-/NIR-Responsive Drug Delivery To Overcome Cancer Chemotherapy Resistance Guided by PET Imaging
文献类型：期刊论文
| 作者 | Zhu, S ; He, X; Yu, J; Xie, JN; Guo, Z; Yan, L; Liu, XF; Wang, Q; Gu, ZJ; Zhao, YL
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| 刊名 | ACS APPLIED MATERIALS & INTERFACES
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| 出版日期 | 2018 |
| 卷号 | 10期号:4页码:4271-4284 |
| 关键词 | MoS2 nanosheets surface modification targeting and P-gp inhibition controlled therapy theranostics |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.7b17506 |
| 文献子类 | Article |
| 英文摘要 | Chemotherapy resistance remains a major hurdle for cancer therapy in clinic because of the poor cellular uptake and insufficient intracellular release of dings. Herein, an intelligent, multifunctional MoS2 nanotheranostic (MoS2-PEI-HA) ingeniously decorated with biodegradable hyaluronic acid (HA) assisted by polyethyleneimine (PEI) is reported to combat drug-resistant breast, cancer (MCF-7-ADR) after loading with the chemotherapy drug doxorubicin (DOX). HA can not only target CD44-overexpressing MCF-7-ADR but also be degraded by hyaluronidase (HAase) that is concentrated in the tumor microenvironment, thus accelerating DOX release. Furthermore, MoS2 with strong near-infrared (NIR) photothermal conversion ability can also promote the release of DOX in the acidic tumor environment at a mild 808 nm laser irradiation, achieving a superior antitumor activity based on the programmed response to HAase and NIR laser actuator. Most importantly, HA targeting combined with mild NIR laser stimuli, rather than using hyperthermia, can potently downregulate the expression of drug resistance-related Pllycoprotein (P-gp), resulting in greatly enhanced intracellular drug accumulation, thus achieving drug resistance reversal. After labeled with Cu-64 by a simple chelation strategy, MoS2 was employed for real-time positron emission tomography (PET) imaging of MCF-7-ADR tumor in vivo. This multifunctional nanoplatform paves a new avenue for PET imaging-guided spatial-temporal-controlled accurate therapy of drug-resistant cancer. |
| WOS关键词 | METAL DICHALCOGENIDE NANOSHEETS ; UP-CONVERSION NANOPARTICLES ; PRODUCT P-GLYCOPROTEIN ; ONE-POT SYNTHESIS ; IN-VIVO ; POLYMERIC MICELLES ; PHOTOTHERMAL THERAPY ; TUMOR ; DOXORUBICIN ; GENE |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000424728800125 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285655]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_实验物理中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Zhu, S,He, X,Yu, J,et al. Intelligent MoS2 Nanotheranostic for Targeted and Enzyme-/pH-/NIR-Responsive Drug Delivery To Overcome Cancer Chemotherapy Resistance Guided by PET Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(4):4271-4284. |
| APA | Zhu, S.,He, X.,Yu, J.,Xie, JN.,Guo, Z.,...&Zhang, X.(2018).Intelligent MoS2 Nanotheranostic for Targeted and Enzyme-/pH-/NIR-Responsive Drug Delivery To Overcome Cancer Chemotherapy Resistance Guided by PET Imaging.ACS APPLIED MATERIALS & INTERFACES,10(4),4271-4284. |
| MLA | Zhu, S,et al."Intelligent MoS2 Nanotheranostic for Targeted and Enzyme-/pH-/NIR-Responsive Drug Delivery To Overcome Cancer Chemotherapy Resistance Guided by PET Imaging".ACS APPLIED MATERIALS & INTERFACES 10.4(2018):4271-4284. |
入库方式： OAI收割
来源：高能物理研究所
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