Transferrin Adsorbed on PEGylated Gold Nanoparticles and Its Relevance to Targeting Specificity
文献类型：期刊论文
| 作者 | Chen, HQ ; Feng, WY; Chen, CY; Chen, J; Wang B(汪冰); Wang, B; Wang, XY; Wang, MZ; Cai, CX; Feng WY(丰伟悦)
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| 刊名 | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
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| 出版日期 | 2018 |
| 卷号 | 18期号:8页码:5306-5313 |
| 关键词 | Gold Nanoparticle Transferrin PEGylation Adsorption Target Delivery |
| ISSN号 | 1533-4880 |
| DOI | 10.1166/jnn.2018.15435 |
| 文献子类 | Article |
| 英文摘要 | Polyethylene glycol (PEG) has been frequently used for surface modification of nanoparticles (NPs) to reduce non-specific binding of proteins on NPs. The investigation of protein absorption on PEGylated nanoparticles is necessary. In the work, the conjugation of transferrin (Tf) to PEGylated AuNPs via adsorption or bonding was studied. The 13 nm AuNPs were coated with various molecular weight (300, 2000, 5000) carboxyl and methoxy PEG thiol. The presence of Tf on PEGylated AuNP was characterized by dynamic light scattering (DLS) and infrared spectroscopy (IR). The data of IR confirmed the presence of Tf on PEGylated AuNPs. The diameter decrease of PEGylated AuNPs after Tf adsorption was observed by DLS measurement, which is attributed to competitive adsorption between Tf and PEG molecules. These phenomena may be important to the preservation of Tf targeting specificity on PEGylated AuNPs. |
| 电子版国际标准刊号 | 1533-4899 |
| WOS关键词 | PROTEIN CORONA ; POLYETHYLENE-GLYCOL ; SURFACE ; RECEPTOR ; NANOCARRIERS ; ANTIBODIES ; ADSORPTION ; IMPACT ; CELLS |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000426059800015 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285687]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 通讯作者 | Feng WY(丰伟悦) |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Chen, HQ,Feng, WY,Chen, CY,et al. Transferrin Adsorbed on PEGylated Gold Nanoparticles and Its Relevance to Targeting Specificity[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2018,18(8):5306-5313. |
| APA | Chen, HQ.,Feng, WY.,Chen, CY.,Chen, J.,汪冰.,...&陈汉清.(2018).Transferrin Adsorbed on PEGylated Gold Nanoparticles and Its Relevance to Targeting Specificity.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,18(8),5306-5313. |
| MLA | Chen, HQ,et al."Transferrin Adsorbed on PEGylated Gold Nanoparticles and Its Relevance to Targeting Specificity".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 18.8(2018):5306-5313. |
入库方式： OAI收割
来源：高能物理研究所
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