Clinical Factors Associated with Brain Volume Reduction in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations
文献类型：期刊论文
| 作者 | Cheng, YQ; Zhao, YY; Yu, HJ; Lai, AY; Lv, ZP; Xu, XF; Luo, CR; Shan, BC; Xu, L ; Liu, S
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| 刊名 | FRONTIERS IN PSYCHIATRY
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| 出版日期 | 2018 |
| 卷号 | 9页码:PMID 8 |
| 关键词 | systemic lupus erythematosus quantitative magnetic resonance imaging brain volume reduction cognitive impairment immunosuppressive agents |
| ISSN号 | 1664-0640 |
| DOI | 10.3389/fpsyt.2018.00008 |
| 文献子类 | Article |
| 英文摘要 | The aim of the study was to find structural brain changes in systemic lupus erythematosus patients without major neuropsychiatric manifestations [non-neuropsychiatric systemic lupus erythematosus (non-NPSLE)] using quantitative magnetic resonance imaging (MRI) and possible associations with clinical characteristics. 89 non-NPSLE patients with normal conventional MRI and 84 healthy controls (HCs) were recruited. The whole brain gray matter volume (GMV) and white matter volume (WMV) were calculated for each individual. We found obvious GMV and WMV reduction in the systemic lupus erythematosus (SLE) group compared with HCs. Female patients showed significant reduction of GMV and WMV compared with male patients. Patients treated with immunosuppressive agents (ISA) showed less WMV reduction than those without. Cognitive impairment was the most common subclinical neuropsychiatric manifestation and had a prevalence of 46.1%. Association between WMV reduction with cognitive impairment was found. Thus, we concluded that structural brain atrophy could happen even before occurrence of obvious neuropsychiatric signs and symptoms and was associated with subclinical symptoms such as cognitive impairment. ISA treatment might have a protective effect on the brain atrophy. Early treatment might prevent the progressive damage to the brain. More studies are needed to fully understand the complicated underlying mechanisms of brain atrophy in SLE. |
| WOS关键词 | CENTRAL-NERVOUS-SYSTEM ; DISEASE-ACTIVITY INDEX ; MAGNETIC-RESONANCE ; INTRAVENOUS CYCLOPHOSPHAMIDE ; ANTIPHOSPHOLIPID ANTIBODIES ; ANTICARDIOLIPIN ANTIBODIES ; HIPPOCAMPAL ATROPHY ; MRI ; DEPRESSION ; GRAY |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000423809500001 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285583]  |
| 专题 | 高能物理研究所_核技术应用研究中心 高能物理研究所_实验物理中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Cheng, YQ,Zhao, YY,Yu, HJ,et al. Clinical Factors Associated with Brain Volume Reduction in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations[J]. FRONTIERS IN PSYCHIATRY,2018,9:PMID 8. |
| APA | Cheng, YQ.,Zhao, YY.,Yu, HJ.,Lai, AY.,Lv, ZP.,...&单保慈.(2018).Clinical Factors Associated with Brain Volume Reduction in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations.FRONTIERS IN PSYCHIATRY,9,PMID 8. |
| MLA | Cheng, YQ,et al."Clinical Factors Associated with Brain Volume Reduction in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations".FRONTIERS IN PSYCHIATRY 9(2018):PMID 8. |
入库方式： OAI收割
来源：高能物理研究所
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