Exposure to Alumina Nanoparticles in Female Mice During Pregnancy Induces Neurodevelopmental Toxicity in the Offspring
文献类型：期刊论文
| 作者 | Niu, Q; Duncan, J; Wu, XH ; Moehling, TJ; Gao, FP; Li, H; He, KH; Ding, Y; Zhang, QL; Gao FP(高福平)
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| 刊名 | FRONTIERS IN PHARMACOLOGY
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| 出版日期 | 2018 |
| 卷号 | 9页码:253 |
| ISSN号 | 1663-9812 |
| 关键词 | alumina nanoparticles developmental neurotoxicity neurodevelopmental toxicity oxidative stress neurotransmitter |
| DOI | 10.3389/fphar.2018.00253 |
| 文献子类 | Article |
| 英文摘要 | Alumina nanoparticles (AlNP) have been shown to accumulate in organs and penetrate biological barriers which lead to toxic effects in many organ systems. However, it is not known whether AlNP exposure to female mice during pregnancy can affect the development of the central nervous system or induce neurodevelopmental toxicity in the offspring. The present study aims to examine the effect of AlNP on neurodevelopment and associated underlying mechanism. ICR strain adult female mice were randomly divided into four groups, which were treated with normal saline (control), 10 mu m particle size of alumina (bulk-Al), and 50 and 13 nm AlNP during entire pregnancy period. Aluminum contents in the hippocampus of newborns were measured and neurodevelopmental behaviors were tracked in the offspring from birth to 1 month of age. Furthermore, oxidative stress and neurotransmitter levels were measured in the cerebral cortex of the adolescents. Our results showed that aluminum contents in the hippocampus of newborns in AlNP-treated groups were significantly higher than those in bulk-Al and controls. Moreover, the offspring delivered by AlNP-treated female mice displayed stunted neurodevelopmental behaviors. Finally, the offspring of AlNP-treated mice demonstrated significantly increased anxiety-like behavior with impaired learning and memory performance at 1 month of age. The underlying mechanism could be related to increased oxidative stress and decreased neurotransmitter levels in the cerebral cortex. We therefore conclude that AlNP exposure of female mice during pregnancy can induce neurodevelopmental toxicity in offspring. |
| WOS关键词 | ZINC-OXIDE NANOPARTICLES ; OXIDATIVE STRESS ; SILVER NANOPARTICLES ; TITANIUM-DIOXIDE ; IN-VIVO ; DEVELOPMENTAL EXPOSURE ; EMBRYONIC-DEVELOPMENT ; AL2O3 NANOPARTICLES ; ZEBRAFISH EMBRYOS ; CARBON NANOTUBES |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000427863800001 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285745]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Niu, Q,Duncan, J,Wu, XH,et al. Exposure to Alumina Nanoparticles in Female Mice During Pregnancy Induces Neurodevelopmental Toxicity in the Offspring[J]. FRONTIERS IN PHARMACOLOGY,2018,9:253. |
| APA | Niu, Q.,Duncan, J.,Wu, XH.,Moehling, TJ.,Gao, FP.,...&高福平.(2018).Exposure to Alumina Nanoparticles in Female Mice During Pregnancy Induces Neurodevelopmental Toxicity in the Offspring.FRONTIERS IN PHARMACOLOGY,9,253. |
| MLA | Niu, Q,et al."Exposure to Alumina Nanoparticles in Female Mice During Pregnancy Induces Neurodevelopmental Toxicity in the Offspring".FRONTIERS IN PHARMACOLOGY 9(2018):253. |
入库方式： OAI收割
来源：高能物理研究所
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