Analyte-Triggered DNA-Probe Release from a Triplex Molecular Beacon for Nanopore Sensing
文献类型：期刊论文
| 作者 | Wu, HC ; Liu, L; Liu, QS; Zhou, K; Sheng, YY; 刘蕾(多); Liu QS(刘全胜); Zhou K(周柯); Guo, BY; Guo BY(郭秉元)
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| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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| 出版日期 | 2018 |
| 卷号 | 57期号:14页码:3602-3606 |
| 关键词 | antibodies biomarkers molecular beacon nanopore sensors quantitative determination |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201711690 |
| 文献子类 | Article |
| 英文摘要 | A new nanopore sensing strategy based on triplex molecular beacon was developed for the detection of specific DNA or multivalent proteins. The sensor is composed of a triplex-forming molecular beacon and a stem-forming DNA component that is modified with a host-guest complex. Upon target DNA hybridizing with the molecular beacon loop or multivalent proteins binding to the recognition elements on the stem, the DNA probe is released and produces highly characteristic current signals when translocated through -hemolysin. The frequency of current signatures can be used to quantify the concentrations of the target molecules. This sensing approach provides a simple, quick, and modular tool for the detection of specific macromolecules with high sensitivity and excellent selectivity. It may find useful applications in point-of-care diagnostics with a portable nanopore kit in the future. |
| 电子版国际标准刊号 | 1521-3773 |
| WOS关键词 | ALPHA-HEMOLYSIN NANOPORE ; CANCER-PATIENTS ; NUCLEIC-ACIDS ; SOLID-STATE ; SINGLE ; PROTEIN ; BIOMARKERS ; ANTIBODY ; DISCRIMINATION ; NANOSTRUCTURES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000428350100008 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285778]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_核技术应用研究中心 |
| 通讯作者 | 刘蕾(多) |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Wu, HC,Liu, L,Liu, QS,et al. Analyte-Triggered DNA-Probe Release from a Triplex Molecular Beacon for Nanopore Sensing[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(14):3602-3606. |
| APA | Wu, HC.,Liu, L.,Liu, QS.,Zhou, K.,Sheng, YY.,...&郭秉元.(2018).Analyte-Triggered DNA-Probe Release from a Triplex Molecular Beacon for Nanopore Sensing.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(14),3602-3606. |
| MLA | Wu, HC,et al."Analyte-Triggered DNA-Probe Release from a Triplex Molecular Beacon for Nanopore Sensing".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.14(2018):3602-3606. |
入库方式： OAI收割
来源：高能物理研究所
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