Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and FXa
文献类型：期刊论文
| 作者 | Li, JX ; Xing GM(邢更妹); Zhao LN(赵丽娜); Gu WH(古伟宏); Chen K(陈奎); Chang YN(常亚男); Liu JK(刘金珂); Zu M(祖勉); Li J(李娟); Xia SB(夏士博)
|
| 刊名 | NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY AND MEDICINE
 |
| 出版日期 | 2018 |
| 卷号 | 14期号:3页码:929-939 |
| 关键词 | Fullerenols Anticoagulation Thrombin FXa Ca2+ Inhibition of thrombosis |
| ISSN号 | 1549-9634 |
| DOI | 10.1016/j.nano.2017.12.013 |
| 文献子类 | Article |
| 英文摘要 | Thrombus is one of main causes of death in the world and also a vital trouble of biomaterials application in vivo. Recently, effect of fullerenol nanomaterials on anticoagulation was found in our research through extension of bleeding times in treated Sprague-Dawley rats via intravenous injection. Inhibiting of fullerenols on thrombosis was ascertained further by thromboembolism model. Effects of fullerenols on intrinsic and extrinsic pathway were distinct in prolonging activated partial thromboplastin time and prothrombin time, which supported that fullerenols induced defects in both pathways. Inhibited activities of activated coagulation factor X (FXa) and thrombin were verified by experiments in vitro and AutoDock Vina. The results suggest that fullerenols depending on small size and certainly surface property occupied the active domain of FXa and thrombin to block their activity; further, thrombosis was inhibited. This putative mechanism offers an insight into how fullerenol NPs were utilized further in biomedical applications. (c) 2018 Elsevier Inc. All rights reserved. |
| 电子版国际标准刊号 | 1549-9642 |
| WOS关键词 | PLATELET-AGGREGATION ; ANTITHROMBOTIC ACTIVITIES ; PROCOAGULANT ACTIVITY ; STEM-CELLS ; IN-VITRO ; FIBRINOGEN ; ANTICOAGULANT ; BINDING ; PERMEABILITY ; SUPPRESSION |
| WOS研究方向 | Science & Technology - Other Topics ; Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000429528900027 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285806]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Li, JX,Xing GM,Zhao LN,et al. Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and FXa[J]. NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY AND MEDICINE,2018,14(3):929-939. |
| APA | Li, JX.,邢更妹.,赵丽娜.,古伟宏.,陈奎.,...&Xing, GY.(2018).Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and FXa.NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY AND MEDICINE,14(3),929-939. |
| MLA | Li, JX,et al."Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and FXa".NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY AND MEDICINE 14.3(2018):929-939. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。