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Tc-99m-labeled DTPA-colchicine dimer with improved tumor uptake

文献类型：期刊论文

作者Zhao, QY; Yang, WJ; Zhang, YH; Xue, JQ; Liu, Y; Wang JJ(汪建军); Yang WJ(杨文江); Xue JQ(薛金泉); Zhang YH(张延华); 刘宇(多)
刊名JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
出版日期2018
卷号61期号:4页码:395-401
关键词Tc-99m DTPA-colchicine dimer label tumor uptake
ISSN号0362-4803
DOI10.1002/jlcr.3611
文献子类Article
英文摘要This work reports the synthesis, radiolabeling, and biological studies of Tc-99m-diethylene triamine pentaacetic acid (DTPA)-colchicine dimer in tumor-bearing mice. The novel colchicine dimer was successfully synthesized by conjugation of DTPA to 2 colchicine biomolecules. The ligand could be labeled by Tc-99m in high yield to get Tc-99m-DTPA-colchicine dimer, which was hydrophilic and stable at room temperature. Biodistribution and imaging studies in tumor-bearing mice showed that Tc-99m-DTPA-colchicine dimer accumulated in the tumor with improved uptake and retention. The results indicate the need for synthetic modification of the parent colchicine derivative and the Tc-99m-chelate with a view to improve the tumor-targeting efficacy and in vivo kinetic profiles.
电子版国际标准刊号1099-1344
WOS关键词PRELIMINARY BIODISTRIBUTION ; IN-VIVO ; RADIOPHARMACEUTICALS ; RESISTANCE ; AGENT ; COMPLEX
WOS研究方向Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:000430669000008
源URL[http://ir.ihep.ac.cn/handle/311005/285853]  
专题高能物理研究所_核技术应用研究中心
高能物理研究所_多学科研究中心
通讯作者Wang JJ(汪建军)
作者单位中国科学院高能物理研究所
推荐引用方式
GB/T 7714		 Zhao, QY,Yang, WJ,Zhang, YH,et al. Tc-99m-labeled DTPA-colchicine dimer with improved tumor uptake[J]. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS,2018,61(4):395-401.
APA Zhao, QY.,Yang, WJ.,Zhang, YH.,Xue, JQ.,Liu, Y.,...&Ma, JP.(2018).Tc-99m-labeled DTPA-colchicine dimer with improved tumor uptake.JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS,61(4),395-401.
MLA Zhao, QY,et al."Tc-99m-labeled DTPA-colchicine dimer with improved tumor uptake".JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 61.4(2018):395-401.

入库方式： OAI收割

来源：高能物理研究所

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