Investigation of the sustained-release mechanism of hydroxypropyl methyl cellulose skeleton type Acipimox tablets
文献类型：期刊论文
| 作者 | Shi RJ(史戎坚) ; Yu, N; Shi, RJ; Liu, WY; Huo, Q; Wang, Y
|
| 刊名 | OPEN CHEMISTRY
 |
| 出版日期 | 2018 |
| 卷号 | 16期号:1页码:333-339 |
| 关键词 | Acipimox sustained-release tablet sodium carboxymethylcellulose hydroxypropyl methyl cellulose |
| ISSN号 | 2391-5420 |
| DOI | 10.1515/chem-2018-0036 |
| 文献子类 | Article |
| 英文摘要 | In this study, we investigate the production of hypolipidemic agents in the form of Acipimox sustained-release tablets, using a wet pelleting process. The purpose of this research is to reduce the total intake time for patients and to lower the initial dose in such that the adverse reactions could be reduced. This study adopts the single-factor method and orthogonal experiments by using hydroxypropyl methyl cellulose (HPMC K15M) as the main sustained-release prescription composition. The final prescription is Acipimox 20%, HPMC K15M 26.67%, sodium carboxymethyl cellulose 30%, polyethylene glycol (PEG 6000) 1%, ethyl cellulose 16.6%, lactose 4.67% and magnesium stearate 1%. The dissolution of tablets reached 85.88% in 8 h. The difference in the weight, hardness and friability of the tables met the requirements in the Chinese Pharmacopoeia; to test the stability, a temperature and illumination accelerated test method was used, the results indicate that the Acipimox sustained-release tablets should be sealed and stored in a dark, cool area. A preliminary study on the tablets' releasing mechanism showed that their release curve fitted the Higuchi model (the formula is M-t/M-infinity = 31.137 t(1/)(2)-3.605 (R-2 = 0.9903)). The Acipimox tablets' release principle is dominated by the diffusion mechanism. |
| WOS关键词 | HEALTHY-VOLUNTEERS ; HYPERTRIGLYCERIDEMIA ; HYPERLIPIDEMIA ; POPULATION ; SINGLE |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000431899300005 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285899]  |
| 专题 | 高能物理研究所_核技术应用研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Shi RJ,Yu, N,Shi, RJ,et al. Investigation of the sustained-release mechanism of hydroxypropyl methyl cellulose skeleton type Acipimox tablets[J]. OPEN CHEMISTRY,2018,16(1):333-339. |
| APA | 史戎坚,Yu, N,Shi, RJ,Liu, WY,Huo, Q,&Wang, Y.(2018).Investigation of the sustained-release mechanism of hydroxypropyl methyl cellulose skeleton type Acipimox tablets.OPEN CHEMISTRY,16(1),333-339. |
| MLA | 史戎坚,et al."Investigation of the sustained-release mechanism of hydroxypropyl methyl cellulose skeleton type Acipimox tablets".OPEN CHEMISTRY 16.1(2018):333-339. |
入库方式： OAI收割
来源：高能物理研究所
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