Significant Enhancement of Photothermal and Photoacoustic Efficiencies for Semiconducting Polymer Nanoparticles through Simply Molecular Engineering
文献类型：期刊论文
| 作者 | Ma, H; Wu, XX; Xu, FJ; Peng, AD; Huang, H; Chen J(陈俊) ; Xie J(谢进); Yang, L; Dong, T; Wen, KK
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| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2018 |
| 卷号 | 28期号:23页码:1800135 |
| 关键词 | molecular engineering photoacoustic imaging photothermal therapy semiconducting polymer nanoparticles tumors |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.201800135 |
| 文献子类 | Article |
| 英文摘要 | Semiconducting polymer nanoparticles (SP NPs) are employed as efficient nanoagents for "all-in-one" theranostic nanoplatforms with dual photoacoustic imaging (PAI) and photothermal therapy (PTT) functions based on their photothermal conversion effect. However, the mechanisms of tuning the PTT efficiency are still elusive, though several SP NPs with high photothermal efficiency are reported. Herein, two donor-acceptor (D-A) SP NPs PTIGSVS and PIIGSVS with the same donor unit but different acceptor units are designed and synthesized. Through tuning the acceptor unit, PTIGSVS shows more planar backbone structure, stronger D-A strength, redshifted absorption, enhanced extinction efficient, weakened emission properties, and more efficient nonradiative decay in comparison to the polymeric analogue PIIGSVS. Thus, PTIGSVS NPs present much higher photothermal conversion efficiencies (74%) than PIIGSVS NPs (11%), resulting in significantly enhanced in vitro and in vivo PAI and PTT performance. This contribution demonstrates that PTIGSVS NPs are superior PA/PTT agents for effective cancer theranostic and shed light on understanding the relationship between molecular structures and photothermal effect of CPs. |
| 电子版国际标准刊号 | 1616-3028 |
| WOS关键词 | MULTIFUNCTIONAL THERANOSTIC AGENT ; CANCER-THERAPY ; LIVING MICE ; ORGANIC NANOPARTICLES ; CONJUGATED POLYMERS ; MOS2 NANOSHEETS ; CONTRAST AGENTS ; DRUG-DELIVERY ; CARBON DOTS ; TUMOR |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000434207800009 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285986]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Ma, H,Wu, XX,Xu, FJ,et al. Significant Enhancement of Photothermal and Photoacoustic Efficiencies for Semiconducting Polymer Nanoparticles through Simply Molecular Engineering[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(23):1800135. |
| APA | Ma, H.,Wu, XX.,Xu, FJ.,Peng, AD.,Huang, H.,...&Fan, WL.(2018).Significant Enhancement of Photothermal and Photoacoustic Efficiencies for Semiconducting Polymer Nanoparticles through Simply Molecular Engineering.ADVANCED FUNCTIONAL MATERIALS,28(23),1800135. |
| MLA | Ma, H,et al."Significant Enhancement of Photothermal and Photoacoustic Efficiencies for Semiconducting Polymer Nanoparticles through Simply Molecular Engineering".ADVANCED FUNCTIONAL MATERIALS 28.23(2018):1800135. |
入库方式： OAI收割
来源：高能物理研究所
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