Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life
文献类型：期刊论文
| 作者 | Gu ZJ(谷战军) ; Gao, JW; Fu, JJ; Fan, XT; Zhu, JC; Gu, ZJ; Xu, HW; Ma, YY; Gong, LJ; Gong LJ(龚林吉)
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| 刊名 | INTERNATIONAL JOURNAL OF NANOMEDICINE
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| 出版日期 | 2018 |
| 卷号 | 13页码:3593-3608 |
| 关键词 | silica nanoparticles nanotoxicity hippocampal neurogenesis neuroinfla mation social behavior |
| ISSN号 | 1178-2013 |
| DOI | 10.2147/IJN.S160828 |
| 文献子类 | Article |
| 英文摘要 | Introduction: Silica nanoparticles (SiO2-NPs) are currently among the most widely used nanomaterials, but their potentially adverse effects on brain development remain unknown. The developing brain is extremely sensitive to NP neurotoxicity during the early postnatal period. Materials and methods: Herein, we investigated the effects of SiO2-N Ps (doses of 10, 20, or 50 mg with a particle size of similar to 91 nm, equivalent to aerosol mass concentrations 55.56, 111.11, and 277.78 mg/m(3), respectively) exposure from postnatal day (P) 1 to P7 on hippocampal precursor proliferation at P8 and long-term neurobehavior in adults. Results: SiO2-NP exposure resulted in inflammatory cell infiltration in lung tissue, microglia over-activation in the hippocampal dentate gyrus (DG), and decreased hippocampal precursor proliferation in the DG-subgranular zone at P8. Moreover, after exposure to 20 mg of SiO2-NPs, mice exhibited social interaction deficits and slight anxiety-like behaviors in adulthood, but this exposure did not induce locomotor activity impairment, depression-like behavior, or short-term memory impairment. Discussion: These findings suggest that early-age SiO2-NP exposure induced inflammation and inhibited precursor proliferation in the DG in a dose-dependent manner, which might be related to the social dysfunction observed in adulthood. |
| WOS关键词 | BRAIN-BARRIER DYSFUNCTION ; NEURAL STEM-CELLS ; IN-VITRO ; INTRATRACHEAL INSTILLATION ; INFLAMMATORY RESPONSES ; DIOXIDE NANOPARTICLES ; ALZHEIMERS-DISEASE ; OXIDATIVE STRESS ; AIR-POLLUTION ; MOUSE MODEL |
| WOS研究方向 | Science & Technology - Other Topics ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000436025200001 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/286042]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Gu ZJ,Gao, JW,Fu, JJ,et al. Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2018,13:3593-3608. |
| APA | 谷战军.,Gao, JW.,Fu, JJ.,Fan, XT.,Zhu, JC.,...&龚林吉.(2018).Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life.INTERNATIONAL JOURNAL OF NANOMEDICINE,13,3593-3608. |
| MLA | 谷战军,et al."Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life".INTERNATIONAL JOURNAL OF NANOMEDICINE 13(2018):3593-3608. |
入库方式： OAI收割
来源：高能物理研究所
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