Walking the line: The fate of nanomaterials at biological barriers
文献类型：期刊论文
| 作者 | Leong, W; Meng, H; Zhao YL(赵宇亮) ; Chen CY(陈春英); Zhao, YL; Chen, CY; Leong, KW
|
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2018 |
| 卷号 | 174页码:41-53 |
| 关键词 | Biological barriers Nano/bio interface Nanomaterials Nanosafety Nanomedicine |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2018.04.056 |
| 文献子类 | Review |
| 英文摘要 | Biological systems have developed an efficient multi-tiered defense system to block foreign substances such as engineered nanomaterials (NMs) from causing damage. In a pathological scenario, the disease itself may also pose additional barriers due to the imbalance between abnormal cells and their surrounding microenvironment, and NMs could behave similarly or differently to classic foreign substances, depending on their unique characteristics. Thus, understanding the mechanisms that govern the fate of NMs against these biological barriers, including the strategies that can be used to shift their fate between access and blockage, become key information for NMs design. In this manuscript, we first describe the biological barriers that NMs may encounter, and further discuss how these biological barrier interactions could shift the fate of NMs between toxicity and therapeutic potential. A list of effects that may influence NMs access at nano/bio interface are presented and discussed, followed by personal insights on the important nano/bio topics that require additional research for a better understanding of NM/biological barrier interactions. (C) 2018 Elsevier Ltd. All rights reserved. |
| 电子版国际标准刊号 | 1878-5905 |
| WOS关键词 | BLOOD-BRAIN-BARRIER ; PREDICTIVE TOXICOLOGICAL APPROACH ; MESOPOROUS SILICA NANOPARTICLES ; HUMAN PANCREATIC-CANCER ; PROTEIN CORONA ; DRUG-DELIVERY ; QUANTUM DOTS ; MACROMOLECULAR THERAPEUTICS ; ENHANCED PERMEABILITY ; SILVER NANOPARTICLES |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000436223500004 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/286058]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 通讯作者 | Zhao YL(赵宇亮) |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Leong, W,Meng, H,Zhao YL,et al. Walking the line: The fate of nanomaterials at biological barriers[J]. BIOMATERIALS,2018,174:41-53. |
| APA | Leong, W.,Meng, H.,赵宇亮.,陈春英.,Zhao, YL.,...&Leong, KW.(2018).Walking the line: The fate of nanomaterials at biological barriers.BIOMATERIALS,174,41-53. |
| MLA | Leong, W,et al."Walking the line: The fate of nanomaterials at biological barriers".BIOMATERIALS 174(2018):41-53. |
入库方式： OAI收割
来源：高能物理研究所
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