Twirling reinforcing-reducing manipulation central mechanism underlying antihypertensive effect on spontaneous hypertension in rats
文献类型：期刊论文
| 作者 | Liu, QG; Sun, DM; Nie, BB ; Nie BB(聂彬彬); Guo, QL
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| 刊名 | JOURNAL OF TRADITIONAL CHINESE MEDICINE
 |
| 出版日期 | 2018 |
| 卷号 | 38期号:3页码:391-398 |
| 关键词 | Twirling reinforcing reducing method Hypertension Blood pressure Positron-Emission tomography Central mechanism |
| ISSN号 | 0255-2922 |
| 文献子类 | Article |
| 英文摘要 | OBJECTIVE: To investigate antihypertensive effect in rats in order to confirm that twirling reinforcing-reducing manipulation (TRRM) might be the central mechanism underlying the action. METHODS: In the study, 18F-2-fluoro-deoxy-D-glucose positron emission tomography (18F-FDG-PET) was employed. Fifity-six spontaneous hypertensive rats (SHRs) were randomly divided into a model group, a single-needle acupuncture (SNA) group, a twirling reinforcing group (SNA + TRF) and a twirling reducing (SNA + TRD) group. Fourteen Wistar rats were assigned to the control group. The acupuncture intervention at Taichong (LR 3) acupoint was administered once daily in the SNA, SNA + TRF and SNA + TRD groups for 14 days, with 1 d interval between the two weeks. The blood pressure (BP) of all rats was measured repeatedly and 18F-FDG-PET scans were conducted on the 14th day. PET images were processed with Statistical Parametric Mapping 8.0. RESULTS: After the intervention, systolic BP showed a significant decrease in the SNA, SNA+TRF and SNA + TRD versus the model groups (all P < 0.01) and in the SNA + TRF and SNA + TRD versus the SNA groups (both P < 0.01), with the SNA + TRD group exhibited the best antihypertensive effect (P < 0.01). The key brain regions activated by TRRM were mainly concentrated in the cerebellum, hippocampus, hypothalamus, medulla oblongata, insular cortex, midbrain, thalamus and visual cortex. CONCLUTION: TRRM could significantly lower the BP of SHRs by improving the cerebral glucose metabolism of the activated key brain regions and the underlying central mechanism may be related to the central rennin-angiotensin system and neurotransmission. (C) 2018 JTCM. All rights reserved. |
| 电子版国际标准刊号 | 1577-7014 |
| WOS关键词 | HYPOTHALAMIC PARAVENTRICULAR NUCLEUS ; SYMPATHETIC VASOMOTOR TONE ; RENIN-ANGIOTENSIN SYSTEM ; BLOOD-PRESSURE ; ROSTROVENTROLATERAL MEDULLA ; ACUPUNCTURE ; BRAIN ; NEURONS ; INPUTS ; TRIAL |
| WOS研究方向 | Integrative & Complementary Medicine |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6260600 |
| WOS记录号 | WOS:000436368600008 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/286059]  |
| 专题 | 高能物理研究所_核技术应用研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Liu, QG,Sun, DM,Nie, BB,et al. Twirling reinforcing-reducing manipulation central mechanism underlying antihypertensive effect on spontaneous hypertension in rats[J]. JOURNAL OF TRADITIONAL CHINESE MEDICINE,2018,38(3):391-398. |
| APA | Liu, QG,Sun, DM,Nie, BB,聂彬彬,&Guo, QL.(2018).Twirling reinforcing-reducing manipulation central mechanism underlying antihypertensive effect on spontaneous hypertension in rats.JOURNAL OF TRADITIONAL CHINESE MEDICINE,38(3),391-398. |
| MLA | Liu, QG,et al."Twirling reinforcing-reducing manipulation central mechanism underlying antihypertensive effect on spontaneous hypertension in rats".JOURNAL OF TRADITIONAL CHINESE MEDICINE 38.3(2018):391-398. |
入库方式： OAI收割
来源：高能物理研究所
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