A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA
文献类型：期刊论文
| 作者 | Nieusma, T; Crowe, JE; Wilson, IA; Ward, AB; Kent, SJ; Bombardi, R; erven, HA; V; Albrecht, RA; Richt, JA |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2018 |
| 卷号 | 9页码:2669 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-018-04704-9 |
| 文献子类 | Article |
| 英文摘要 | The high rate of antigenic drift in seasonal influenza viruses necessitates frequent changes in vaccine composition. Recent seasonal H3 vaccines do not protect against swine-origin H3N2 variant (H3N2v) strains that recently have caused severe human infections. Here, we report a human V(H)1-69 gene-encoded monoclonal antibody (mAb) designated H3v-47 that exhibits potent cross-reactive neutralization activity against human and swine H3N2 viruses that circulated since 1989. The crystal structure and electron microscopy reconstruction of H3v-47 Fab with the H3N2v hemagglutinin (HA) identify a unique epitope spanning the vestigial esterase and receptor-binding subdomains that is distinct from that of any known neutralizing antibody for influenza A H3 viruses. MAb H3v-47 functions largely by blocking viral egress from infected cells. Interestingly, H3v-47 also engages Fc gamma receptor and mediates antibody dependent cellular cytotoxicity (ADCC). This newly identified conserved epitope can be used in design of novel immunogens for development of broadly protective H3 vaccines. |
| WOS关键词 | DEPENDENT CELLULAR CYTOTOXICITY ; RESPIRATORY SYNCYTIAL-VIRUS ; RECEPTOR-BINDING SITE ; UNITED-STATES ; A VIRUS ; HUMAN INFECTIONS ; HEMAGGLUTININ ; VARIANT ; RECOGNITION ; RESOLUTION |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000438031000007 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/286106]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Nieusma, T,Crowe, JE,Wilson, IA,et al. A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA[J]. NATURE COMMUNICATIONS,2018,9:2669. |
| APA | Nieusma, T.,Crowe, JE.,Wilson, IA.,Ward, AB.,Kent, SJ.,...&Bangaru, S.(2018).A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA.NATURE COMMUNICATIONS,9,2669. |
| MLA | Nieusma, T,et al."A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA".NATURE COMMUNICATIONS 9(2018):2669. |
入库方式： OAI收割
来源：高能物理研究所
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