Toxicity of silicon dioxide nanoparticles with varying sizes on the cornea and protein corona as a strategy for therapy
文献类型：期刊论文
| 作者 | Sun, DY; Gong, LJ; Xie, J; Gu, XL; Li, YJ; Cao, QL; Li, QY; Luodan, A; Gu, ZJ ; Xu, HW
|
| 刊名 | SCIENCE BULLETIN
 |
| 出版日期 | 2018 |
| 卷号 | 63期号:14页码:907-916 |
| 关键词 | Particulate matter Silicon dioxide nanoparticles Cornea Toxicity Foetal bovine serum |
| ISSN号 | 2095-9273 |
| DOI | 10.1016/j.scib.2018.05.037 |
| 文献子类 | Article |
| 英文摘要 | The human cornea is exposed directly to particulate matter (PM) in polluted air. This exposure can cause eye discomfort and corneal injury. Ultrafine PM (diameter <100 nm) is thought to be particularly harmful to health, but there is limited research investigating its toxicity to the eye. In this study, we evaluated toxicity differences among 30-, 40-, 100-and 150-nm silicon dioxide nanoparticles (SiO2 NPs) on the cornea. A 24-hour in vitro exposure of primary human corneal epithelial cells (hCECs) to ultrafine (30 and 40 nm) SiO2 NPs produced toxicity, as evidenced by cell membrane damage, reduced cell viability, increased cell death and mitochondrial dysfunction. In vivo exposure to the same nanoparticles produced observable corneal injury. These effects were more severe with ultrafine than with fine (100 and 150 nm) SiO2 NPs. Common antioxidant compounds, e.g., glutathione, did not protect the cornea from SiO2 NP-induced damage. However, foetal bovine serum (FBS) did significantly reduce toxicity, likely by forming a protective protein corona around the nanoparticles. This finding suggests that FBS (or its derivatives) may be a useful clinical therapy for corneal toxicity caused by ultrafine particulates. (C) 2018 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved. |
| 电子版国际标准刊号 | 2095-9281 |
| WOS关键词 | EPITHELIAL-CELLS ; PARTICULATE MATTER ; AIR-POLLUTION ; OXIDATIVE STRESS ; MITOCHONDRIA ; RESVERATROL ; MECHANISMS ; RESPONSES ; EXPOSURE ; AMBIENT |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6336977 |
| WOS记录号 | WOS:000439778600007 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/286149]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 通讯作者 | Gu ZJ(谷战军) |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Sun, DY,Gong, LJ,Xie, J,et al. Toxicity of silicon dioxide nanoparticles with varying sizes on the cornea and protein corona as a strategy for therapy[J]. SCIENCE BULLETIN,2018,63(14):907-916. |
| APA | Sun, DY.,Gong, LJ.,Xie, J.,Gu, XL.,Li, YJ.,...&谷战军.(2018).Toxicity of silicon dioxide nanoparticles with varying sizes on the cornea and protein corona as a strategy for therapy.SCIENCE BULLETIN,63(14),907-916. |
| MLA | Sun, DY,et al."Toxicity of silicon dioxide nanoparticles with varying sizes on the cornea and protein corona as a strategy for therapy".SCIENCE BULLETIN 63.14(2018):907-916. |
入库方式： OAI收割
来源：高能物理研究所
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