中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Sleeve Gastrectomy Recovering Disordered Brain Function in Subjects with Obesity: a Longitudinal fMRI Study

文献类型:期刊论文

作者Nie BB(聂彬彬); Li, DM; Ma, L; Gao, HK; Du, J; Guo, YL; Dong, GH; Zhang, TH; Huang, Q; Duan, SF
刊名OBESITY SURGERY
出版日期2018
卷号28期号:8页码:2421-2428
ISSN号0960-8923
关键词Magnetic resonance imaging Obesity Bariatric surgery Functional connectivity Brain
DOI10.1007/s11695-018-3178-z
文献子类Article
英文摘要Bariatric surgery could recover regional dysfunction of cerebral cortex. However, it is unknown whether bariatric surgery could recover the global-level dysfunction in subjects with obesity. The aim of this study was to investigate the effect of bariatric surgery on global-level dysfunction in subjects with obesity by resting-state functional magnetic resonance imaging (fMRI). Resting-state fMRI was used to investigate dysfunction of whole-brain in 34 subjects with obesity and 34 age-and gender-matched normal-weight subjects, in which 17 subjects with obesity received sleeve gastrectomy. Fractional amplitude of low-frequency fluctuation (fALFF) and functional connectivity (FC) among the whole brain were used to estimate the brain functional differences among the preoperative subjects, postoperative subjects, and the controls. The preoperative subjects compared to controls had decreased resting-state activities in reward processing and cognitive control regions such as orbitofrontal cortex, middle frontal gyrus, superior frontal gyrus, and gyrus rectus. It was important that increased FC was also found in these regions. Correlation analysis showed that body mass index (BMI) was associated with these decreased activity and increased FC. More importantly, the dysfunction in these regions was recovered by the bariatric surgery. These results suggest that bariatric surgery-induced weight loss could reverse the global-level dysfunction in subjects with obesity. The dysfunction in these regions might play a key role in the development of obesity, which might serve as a biomarker in the treatment of obesity.
电子版国际标准刊号1708-0428
WOS关键词Y GASTRIC BYPASS ; BARIATRIC SURGERY ; PREFRONTAL CORTEX ; WEIGHT-LOSS ; BODY-MASS ; MORBIDLY OBESE ; CONNECTIVITY ; FOOD ; WOMEN ; METABOLISM
WOS研究方向Surgery
语种英语
WOS记录号WOS:000440156300034
源URL[http://ir.ihep.ac.cn/handle/311005/286162]  
专题高能物理研究所_核技术应用研究中心
通讯作者Dan BC(单保慈)
作者单位中国科学院高能物理研究所
推荐引用方式
GB/T 7714
Nie BB,Li, DM,Ma, L,et al. Sleeve Gastrectomy Recovering Disordered Brain Function in Subjects with Obesity: a Longitudinal fMRI Study[J]. OBESITY SURGERY,2018,28(8):2421-2428.
APA 聂彬彬.,Li, DM.,Ma, L.,Gao, HK.,Du, J.,...&李盼龙.(2018).Sleeve Gastrectomy Recovering Disordered Brain Function in Subjects with Obesity: a Longitudinal fMRI Study.OBESITY SURGERY,28(8),2421-2428.
MLA 聂彬彬,et al."Sleeve Gastrectomy Recovering Disordered Brain Function in Subjects with Obesity: a Longitudinal fMRI Study".OBESITY SURGERY 28.8(2018):2421-2428.

入库方式: OAI收割

来源:高能物理研究所

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