Sleeve Gastrectomy Recovering Disordered Brain Function in Subjects with Obesity: a Longitudinal fMRI Study
文献类型:期刊论文
作者 | Nie BB(聂彬彬); Li, DM; Ma, L; Gao, HK; Du, J; Guo, YL; Dong, GH; Zhang, TH; Huang, Q; Duan, SF |
刊名 | OBESITY SURGERY |
出版日期 | 2018 |
卷号 | 28期号:8页码:2421-2428 |
ISSN号 | 0960-8923 |
关键词 | Magnetic resonance imaging Obesity Bariatric surgery Functional connectivity Brain |
DOI | 10.1007/s11695-018-3178-z |
文献子类 | Article |
英文摘要 | Bariatric surgery could recover regional dysfunction of cerebral cortex. However, it is unknown whether bariatric surgery could recover the global-level dysfunction in subjects with obesity. The aim of this study was to investigate the effect of bariatric surgery on global-level dysfunction in subjects with obesity by resting-state functional magnetic resonance imaging (fMRI). Resting-state fMRI was used to investigate dysfunction of whole-brain in 34 subjects with obesity and 34 age-and gender-matched normal-weight subjects, in which 17 subjects with obesity received sleeve gastrectomy. Fractional amplitude of low-frequency fluctuation (fALFF) and functional connectivity (FC) among the whole brain were used to estimate the brain functional differences among the preoperative subjects, postoperative subjects, and the controls. The preoperative subjects compared to controls had decreased resting-state activities in reward processing and cognitive control regions such as orbitofrontal cortex, middle frontal gyrus, superior frontal gyrus, and gyrus rectus. It was important that increased FC was also found in these regions. Correlation analysis showed that body mass index (BMI) was associated with these decreased activity and increased FC. More importantly, the dysfunction in these regions was recovered by the bariatric surgery. These results suggest that bariatric surgery-induced weight loss could reverse the global-level dysfunction in subjects with obesity. The dysfunction in these regions might play a key role in the development of obesity, which might serve as a biomarker in the treatment of obesity. |
电子版国际标准刊号 | 1708-0428 |
WOS关键词 | Y GASTRIC BYPASS ; BARIATRIC SURGERY ; PREFRONTAL CORTEX ; WEIGHT-LOSS ; BODY-MASS ; MORBIDLY OBESE ; CONNECTIVITY ; FOOD ; WOMEN ; METABOLISM |
WOS研究方向 | Surgery |
语种 | 英语 |
WOS记录号 | WOS:000440156300034 |
源URL | [http://ir.ihep.ac.cn/handle/311005/286162] |
专题 | 高能物理研究所_核技术应用研究中心 |
通讯作者 | Dan BC(单保慈) |
作者单位 | 中国科学院高能物理研究所 |
推荐引用方式 GB/T 7714 | Nie BB,Li, DM,Ma, L,et al. Sleeve Gastrectomy Recovering Disordered Brain Function in Subjects with Obesity: a Longitudinal fMRI Study[J]. OBESITY SURGERY,2018,28(8):2421-2428. |
APA | 聂彬彬.,Li, DM.,Ma, L.,Gao, HK.,Du, J.,...&李盼龙.(2018).Sleeve Gastrectomy Recovering Disordered Brain Function in Subjects with Obesity: a Longitudinal fMRI Study.OBESITY SURGERY,28(8),2421-2428. |
MLA | 聂彬彬,et al."Sleeve Gastrectomy Recovering Disordered Brain Function in Subjects with Obesity: a Longitudinal fMRI Study".OBESITY SURGERY 28.8(2018):2421-2428. |
入库方式: OAI收割
来源:高能物理研究所
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