Associations Among Suicidal Ideation, White Matter Integrity and Cognitive Deficit in First-Episode Schizophrenia
文献类型：期刊论文
| 作者 | Dan BC(单保慈) ; Long, YC; Ouyang, X; Liu, ZN; Chen, XD; Hu, XR; Lee, E; Chen, EYH; Pu, WD; Shan, BC
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| 刊名 | FRONTIERS IN PSYCHIATRY
 |
| 出版日期 | 2018 |
| 卷号 | 9页码:391 |
| 关键词 | first-episode schizophrenia suicide suicidal ideation diffusion tensor imaging (DTI) white matter cognitive function |
| ISSN号 | 1664-0640 |
| DOI | 10.3389/fpsyt.2018.00391 |
| 文献子类 | Article |
| 英文摘要 | Objective: The study was aimed to investigate the possible associations among suicidal ideation, brain white matter (WM) integrity and cognitive deficit in first-episode schizophrenia (FES) using diffusion tensor imaging. Methods: The sample contained 18 FES patients with suicidal ideation (SI+), 45 FES patients without suicidal ideation (SI-) and 44 healthy controls. The Calgary Depression Scale for Schizophrenia was used to measure the suicidal ideation and depression symptoms. The whole brain WM integrity and three domains of cognitive function: working memory, verbal comprehension as well as processing speed were compared between the three groups. Results: Compared with SI-, SI+ showed preserved WM integrity as indicated by significantly higher factional anisotropy (FA) or lower mean diffusivity (MD) in multiple WM tracts, and higher FA coupled with lower MD in bilateral posterior corona radiata. Compared with SI-, SI+ were more depressed and had less cognitive deficit in working memory and verbal comprehension. The fiber tracts in bilateral posterior corona radiata connect to the precuneus as shown by probabilistic tractography, and their WM integrity disruptions were found to be positively associated with the cognitive deficits in the FES patients. Discussion: Preserved WM integrity may be a risk factor for suicidal ideation in FES patients. One possible explanation is that it contributes to preserved cognitive function, especially in working memory and verbal comprehension, which may be associated with greater insight and could lead to increased depression and suicidal ideation. The posterior corona radiata and the precuneus may be linked to the related biological processes. |
| WOS关键词 | 1ST-EPISODE PSYCHOSIS ; NEUROCOGNITIVE FUNCTION ; FUNCTIONAL CONNECTIVITY ; INSIGHT DIMENSIONS ; DEFAULT MODE ; WHOLE-BRAIN ; DIFFUSION ; BEHAVIOR ; MICROSTRUCTURE ; ABNORMALITIES |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000442884700001 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/286245]  |
| 专题 | 高能物理研究所_核技术应用研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Dan BC,Long, YC,Ouyang, X,et al. Associations Among Suicidal Ideation, White Matter Integrity and Cognitive Deficit in First-Episode Schizophrenia[J]. FRONTIERS IN PSYCHIATRY,2018,9:391. |
| APA | 单保慈.,Long, YC.,Ouyang, X.,Liu, ZN.,Chen, XD.,...&Rohrbaugh, RM.(2018).Associations Among Suicidal Ideation, White Matter Integrity and Cognitive Deficit in First-Episode Schizophrenia.FRONTIERS IN PSYCHIATRY,9,391. |
| MLA | 单保慈,et al."Associations Among Suicidal Ideation, White Matter Integrity and Cognitive Deficit in First-Episode Schizophrenia".FRONTIERS IN PSYCHIATRY 9(2018):391. |
入库方式： OAI收割
来源：高能物理研究所
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