A Size-Reducible Nanodrug with an Aggregation-Enhanced Photodynamic Effect for Deep Chemo-Photodynamic Therapy
文献类型：期刊论文
| 作者 | Yin WY(尹文艳) ; Dong XH(董兴华); Gao Q(高琴); Ji, CD; Yin, MZ; Gan, ZH; Zhao, YL; Gu, ZJ; Yin, WY; Dong, XH
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| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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| 出版日期 | 2018 |
| 卷号 | 57期号:35页码:11384-11388 |
| 关键词 | aggregation-enhanced photodynamic effect multifunctionality nanodrugs pentamethine indocyanine size reducibility |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201807602 |
| 文献子类 | Article |
| 英文摘要 | Fluorescent dyes with multi-functionality are of great interest for photo-based cancer theranostics. However, their low singlet oxygen quantum yield impedes their potential applications for photodynamic therapy (PDT). Now, a molecular self-assembly strategy is presented for a nanodrug with a remarkably enhanced photodynamic effect based on a dye-chemodrug conjugate. The self-assembled nanodrug possesses an increased intersystem crossing rate owing to the aggregation of dye, leading to a distinct singlet oxygen quantum yield (Phi(O-1(2))). Subsequently, upon red light irradiation, the generated singlet oxygen reduces the size of the nanodrug from 90 to 10 nm, which facilitates deep tumor penetration of the nanodrug and release of chemodrug. The nanodrug achieved insitu tumor imaging and potent tumor inhibition by deep chemo-PDT. Our work verifies a facile and effective self-assembly strategy to construct nanodrugs with enhanced performance for cancer theranostics. |
| 电子版国际标准刊号 | 1521-3773 |
| WOS关键词 | CANCER-THERAPY ; IN-VIVO ; DRUG ; NANOPARTICLES ; TUMOR ; EFFICIENT ; PHOTOSENSITIZERS ; PENETRATION ; COMBINATION ; CONJUGATE |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000442340000048 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/286280]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_实验物理中心 |
| 通讯作者 | Yin WY(尹文艳) |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Yin WY,Dong XH,Gao Q,et al. A Size-Reducible Nanodrug with an Aggregation-Enhanced Photodynamic Effect for Deep Chemo-Photodynamic Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(35):11384-11388. |
| APA | 尹文艳.,董兴华.,高琴.,Ji, CD.,Yin, MZ.,...&谷战军.(2018).A Size-Reducible Nanodrug with an Aggregation-Enhanced Photodynamic Effect for Deep Chemo-Photodynamic Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(35),11384-11388. |
| MLA | 尹文艳,et al."A Size-Reducible Nanodrug with an Aggregation-Enhanced Photodynamic Effect for Deep Chemo-Photodynamic Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.35(2018):11384-11388. |
入库方式： OAI收割
来源：高能物理研究所
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