Frequency Shift Raman-Based Sensing of Serum MicroRNAs for Early Diagnosis and Discrimination of Primary Liver Cancers
文献类型：期刊论文
| 作者 | Xie, D; Zeng, QD; Hutchison, JA; Li, M; Zuo, D; Zhao, YL ; Zhang, N; Cheng, LX; Zhuang, HJ; Zhu WF(朱文凤)
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| 刊名 | ANALYTICAL CHEMISTRY
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| 出版日期 | 2018 |
| 卷号 | 90期号:17页码:10144-10151 |
| ISSN号 | 0003-2700 |
| DOI | 10.1021/acs.analchem.8b01798 |
| 文献子类 | Article |
| 英文摘要 | Frequency shift surface-enhanced Raman scattering (SERS) achieves multiplex microRNA sensing for early serological diagnosis of, and discrimination between, primary liver cancers in a patient cohort for whom only biopsy is effective clinically. Raman reporters microprinted on plasmonic substrates shift their vibrational frequencies upon biomarker binding with a dynamic range allowing direct, multiplex assay of serum microRNAs and the current best protein biomarker, alpha-fetoprotein. Benchmarking against current gold-standard polymerase chain reaction and chemiluminescence methods validates the assay. The work further establishes the frequency shift approach, sensing shifts in an intense SERS band, as a viable alternative to conventional SERS sensing which involves the more difficult task of resolving a peak above noise at ultralow analyte concentrations. |
| 电子版国际标准刊号 | 1520-6882 |
| WOS关键词 | HEPATOCELLULAR-CARCINOMA ; SPECTROSCOPY ; HYBRIDIZATION ; INFECTION ; DISEASE ; TRENDS ; DNA |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000444060600012 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/286290]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Xie, D,Zeng, QD,Hutchison, JA,et al. Frequency Shift Raman-Based Sensing of Serum MicroRNAs for Early Diagnosis and Discrimination of Primary Liver Cancers[J]. ANALYTICAL CHEMISTRY,2018,90(17):10144-10151. |
| APA | Xie, D.,Zeng, QD.,Hutchison, JA.,Li, M.,Zuo, D.,...&Zhu, WF.(2018).Frequency Shift Raman-Based Sensing of Serum MicroRNAs for Early Diagnosis and Discrimination of Primary Liver Cancers.ANALYTICAL CHEMISTRY,90(17),10144-10151. |
| MLA | Xie, D,et al."Frequency Shift Raman-Based Sensing of Serum MicroRNAs for Early Diagnosis and Discrimination of Primary Liver Cancers".ANALYTICAL CHEMISTRY 90.17(2018):10144-10151. |
入库方式： OAI收割
来源：高能物理研究所
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