Abnormal Metabolic Connectivity in Rats at the Acute Stage of Ischemic Stroke
文献类型：期刊论文
| 作者 | Duan SF(段绍峰) ; Zhao, SJ; Tao, J; Liu, WL; Dong, J; Liu, H; Sun, X; Huang, Q; Zhang, TH; Duan, SF
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| 刊名 | NEUROSCIENCE BULLETIN
 |
| 出版日期 | 2018 |
| 卷号 | 34期号:5页码:715-724 |
| ISSN号 | 1673-7067 |
| 关键词 | Ischemic stroke FDG PET Metabolic connectivity Acute |
| DOI | 10.1007/s12264-018-0266-y |
| 文献子类 | Article |
| 英文摘要 | Stroke at the acute stage is a major cause of disability in adults, and is associated with dysfunction of brain networks. However, the mechanisms underlying changes in brain connectivity in stroke are far from fully elucidated. In the present study, we investigated brain metabolism and metabolic connectivity in a rat ischemic stroke model of middle cerebral artery occlusion (MCAO) at the acute stage using F-18-fluorodeoxyglucose positron emission tomography. Voxel-wise analysis showed decreased metabolism mainly in the ipsilesional hemisphere, and increased metabolism mainly in the contralesional cerebellum. We used further metabolic connectivity analysis to explore the brain metabolic network in MCAO. Compared to sham controls, rats with MCAO showed most significantly reduced nodal and local efficiency in the ipsilesional striatum. In addition, the MCAO group showed decreased metabolic central connection of the ipsilesional striatum with the ipsilesional cerebellum, ipsilesional hippocampus, and bilateral hypothalamus. Taken together, the present study demonstrated abnormal metabolic connectivity in rats at the acute stage of ischemic stroke, which might provide insight into clinical research. |
| 电子版国际标准刊号 | 1995-8218 |
| WOS关键词 | STATE FUNCTIONAL CONNECTIVITY ; CEREBRAL-ISCHEMIA ; MOTOR RECOVERY ; PAXINOS SPACE ; BRAIN ; INJURY ; ELECTROACUPUNCTURE ; INTEGRITY ; NETWORKS ; DISEASE |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6336298 |
| WOS记录号 | WOS:000444005200001 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/286292]  |
| 专题 | 高能物理研究所_核技术应用研究中心 高能物理研究所_实验物理中心 |
| 通讯作者 | Nie BB(聂彬彬) |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Duan SF,Zhao, SJ,Tao, J,et al. Abnormal Metabolic Connectivity in Rats at the Acute Stage of Ischemic Stroke[J]. NEUROSCIENCE BULLETIN,2018,34(5):715-724. |
| APA | 段绍峰.,Zhao, SJ.,Tao, J.,Liu, WL.,Dong, J.,...&梁胜祥.(2018).Abnormal Metabolic Connectivity in Rats at the Acute Stage of Ischemic Stroke.NEUROSCIENCE BULLETIN,34(5),715-724. |
| MLA | 段绍峰,et al."Abnormal Metabolic Connectivity in Rats at the Acute Stage of Ischemic Stroke".NEUROSCIENCE BULLETIN 34.5(2018):715-724. |
入库方式： OAI收割
来源：高能物理研究所
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