Voxel-based morphology analysis of STZ-induced type 1 diabetes mellitus rats with and without cognitive impairment
文献类型：期刊论文
| 作者 | Li, XL; Zhou, Y; Xie, HL; Nie BB(聂彬彬) ; Sun, ZR; Zhao, Y; Nie, BB; Cao, DN
|
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2018 |
| 卷号 | 684页码:210-217 |
| ISSN号 | 0304-3940 |
| 关键词 | Diabetes Cognitive impairment Magnetic resonance imaging Voxel-based morphology |
| DOI | 10.1016/j.neulet.2018.08.017 |
| 文献子类 | Article |
| 英文摘要 | Incidence of diabetes has increased dramatically. Consequently, diabetes-induced cognitive impairment has attracted increasing attention. This study aimed to explore the changes in brain structure in the diabetic rats with and without cognitive impairment. Morris water maze method was used for screening the diabetic rats with/without cognitive impairment. These diabetic rats and controls were imaged using magnetic resonance imaging that segmented into gray and white matter, which was further analyzed using voxel-based morphology (VBM) and regions of interest (ROI) based image retrieval. The ROI results showed that the whole brain volume decreased in diabetic rats with/without cognitive impairment as compared to the control (P < 0.05). The VBM results showed differences in the caudate putamen and prefrontal cortex in the diabetic rats with/without cognitive impairment. The change in the brain of rats with cognitive impairment occurred primarily in the area associated with cognition, such as caudate putamen and hippocampus, and the bi-directional change occurred in the different area of hippocampus. The current results provided important imaging information for early diagnosis and timely treatment of diabetic cognitive impairment. |
| 电子版国际标准刊号 | 1872-7972 |
| WOS关键词 | BRAIN ; ASSOCIATION ; VOLUME |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000445986800035 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/286400]  |
| 专题 | 高能物理研究所_核技术应用研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Li, XL,Zhou, Y,Xie, HL,et al. Voxel-based morphology analysis of STZ-induced type 1 diabetes mellitus rats with and without cognitive impairment[J]. NEUROSCIENCE LETTERS,2018,684:210-217. |
| APA | Li, XL.,Zhou, Y.,Xie, HL.,聂彬彬.,Sun, ZR.,...&Cao, DN.(2018).Voxel-based morphology analysis of STZ-induced type 1 diabetes mellitus rats with and without cognitive impairment.NEUROSCIENCE LETTERS,684,210-217. |
| MLA | Li, XL,et al."Voxel-based morphology analysis of STZ-induced type 1 diabetes mellitus rats with and without cognitive impairment".NEUROSCIENCE LETTERS 684(2018):210-217. |
入库方式： OAI收割
来源：高能物理研究所
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